补肾调周法联合来曲唑治疗卵泡发育不良的临床研究

发布时间：2018-06-29 21:35

本文选题：中西医结合治疗 + 临床研究　；参考：《扬州大学》2016年硕士论文

【摘要】：目的：通过临床研究,探讨中药联合来曲唑与单纯应用中药补肾调周疗法和单纯应用来曲唑对卵泡发育不良的治疗效果。通过比较临床症状、卵泡发育状况、内膜厚度、妊娠率等各方面的差异,获得针对不同卵泡发育不良患者的最佳疗法。方法：选自2013年09月至2015年08月,在扬州市第一人民医院(西区),按照临床诊断标准选取90例卵泡发育不良的患者。随机分组,每组各30例,分别为中药组、西药组以及中药联合西药组(以下称联合组)。西药组口服来曲唑,于月经来潮第五天开始口服。中药组按月经周期口服补肾调周方治疗,联合组按月经周期口服补肾调周方同时并用来曲唑治疗,三组均治疗三个月。按照病例排除标准,剔除不符合病例后,总结得：西药组29例；中药组29例；联合用药组30例。记录患者治疗前后的卵泡大小、内膜厚度、E2、临床积分、妊娠率等情况；所得数据采用SPSS16.0统计分析软件处理,计量数据用均数士标准差(x±s)表达；采取单因素方差分析统计样本治疗前有无差异性,治疗前后资料进行配对样本的t检验；组间比较用独立样本的t检验；计数资料用卡方检验。结果：治疗前后相比,三组患者在临床症状、卵泡发育状况、排卵率、子宫内膜厚度均有改善(P0.05)；治疗后组间比较,在卵泡发育上中药组与联合组之间P0.05,联合组优于中药组；内膜厚度上西药组与联合组在内膜厚度上存在差异P0.05,联合组优于西药组；在临床症状的治疗上,中药组与联合组要优于西药组P0.05；联合组的妊娠率要高于西药组P0.05；联合组的卵泡成熟率高于中药组P0.05；联合组在排卵后的黄体功能优于西药组P0.05；中药组、西药组的E2水平、LUFS的发生率均与联合组无明显差别P0.05。结论：中药联合来曲唑应用在缩短治疗周期,改善患者临床症状、提高排卵率、妊娠率增加子宫内膜厚度,提高黄体功能等方面明显优于单纯应用中药或单纯应用西药。
[Abstract]:Objective: to investigate the therapeutic effect of traditional Chinese medicine combined with letrozole on follicular dysplasia with traditional Chinese medicine (TCM) combined with traditional Chinese medicine (TCM) for tonifying the kidney and regulating the week. By comparing the clinical symptoms, follicular development, intimal thickness and pregnancy rate, the best treatment for patients with different follicular dysplasia was obtained. Methods: from September 2013 to August 2015, 90 patients with follicular dysplasia were selected in Yangzhou first people's Hospital (Western region) according to clinical diagnostic criteria. They were randomly divided into three groups: the traditional Chinese medicine group, the western medicine group and the combined Chinese medicine group (hereinafter referred to as the combined group). The western medicine group took letrozole orally and began on the fifth day of menstruation. The traditional Chinese medicine group was treated by oral tonifying kidney and weekly prescription according to menstrual cycle, and the combined group was treated with triazole simultaneously according to menstrual cycle. All the three groups were treated for three months. According to the criteria of exclusion of cases, the results were summarized as follows: 29 cases in western medicine group, 29 cases in traditional Chinese medicine group and 30 cases in combination group. The follicle size, intimal thickness, clinical score, pregnancy rate and so on were recorded before and after treatment, the data were processed by SPSS 16.0 statistical analysis software, and the measured data were expressed by the mean standard deviation (x 卤s). Single factor analysis of variance (ANOVA) was used to analyze whether there was any difference before and after treatment. Before and after treatment, the matched samples were tested by t test; the independent samples were used by t test for the comparison between groups; and the counting data were tested by chi-square test. Results: compared with before and after treatment, the clinical symptoms, follicle development, ovulation rate and endometrial thickness of the three groups were improved (P0.05), and after treatment, the Chinese medicine group and the combined group were better than the traditional Chinese medicine group in follicular development (P 0.05). There was a difference in intimal thickness between the western medicine group and the combined group (P 0.05), the combination group was superior to the western medicine group, the traditional Chinese medicine group and the combined group were better than the western medicine group (P 0.05) in the treatment of clinical symptoms, the pregnancy rate of the combined group was higher than that of the western medicine group (P 0.05). The follicular maturation rate in the combined group was higher than that in the traditional Chinese medicine group, the luteal function after ovulation in the combined group was better than that in the western medicine group (P0.05), and the incidence of E2 level and LUFS in the traditional Chinese medicine group and western medicine group were not significantly different from those in the combined group (P 0.05). Conclusion: traditional Chinese medicine combined with letrozole is superior to traditional Chinese medicine or western medicine in shortening treatment cycle, improving clinical symptoms, increasing ovulation rate, increasing endometrial thickness and improving luteal function.
【学位授予单位】：扬州大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R711.6

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