复苏周期D5单囊胚移植与双囊胚移植对妊娠结局的影响

发布时间：2018-07-04 12:43

本文选题：复苏周期 + 单囊胚移植　；参考：《生殖医学杂志》2016年12期

【摘要】：目的探讨复苏周期第5天(D5)单囊胚移植与双囊胚移植对年龄35岁、卵巢储备正常的不育症患者妊娠结局的影响。方法回顾性分析2013年1月至2015年4月我中心466例年龄35岁、卵巢储备正常的不育症患者复苏周期D5囊胚移植的妊娠结局,根据D5囊胚移植个数分为D5单囊胚移植组(207例)与D5双囊胚移植组(259例),对两组的妊娠结局进行比较。结果两组的生化妊娠率、临床妊娠率、活产率、异位妊娠率、流产率及单卵双胎率比较均无显著性差异(P0.05);双囊胚移植组的多胎妊娠率显著高于单囊胚移植组(52.6%vs.2.4%)(P0.001);单囊胚移植组的种植率显著高于双囊胚移植组(79.2%vs.57.5%)(P0.001);新生儿基本情况的统计显示,单囊胚移植组新生儿的胎龄及平均出生体重均显著大于双囊胚移植组[分别为(38.6±2.1)周vs.(37.4±2.4)周,(3 282.0±523.4)g vs.(2 937.9±645.5)g](P0.001)。结论对于年龄35岁、卵巢储备正常,新鲜周期未移植且为第一次复苏周期D5囊胚移植的患者,可以建议行D5单囊胚移植,其能获得与D5双囊胚移植相似的活产率,并能显著降低多胎率、延长孕周并改善新生儿出生体重。
[Abstract]:Objective to investigate the effect of single blastocyst transplantation (D5) and double blastocyst transplantation (D5) on pregnancy outcome in infertile patients aged 35 years with normal ovarian reserve. Methods from January 2013 to April 2015, the pregnancy outcomes of 466 infertile patients aged 35 years with normal ovarian reserve during D5 blastocyst transplantation were retrospectively analyzed. According to the number of D 5 blastocysts, we divided them into two groups: D5 single blastocyst transplantation group (207 cases) and D5 double blastocyst transplantation group (259 cases). The pregnancy outcomes of the two groups were compared. Results the biochemical pregnancy rate, clinical pregnancy rate, live delivery rate, ectopic pregnancy rate of the two groups, There was no significant difference in abortion rate and single egg twin embryo rate (P0.05), the multiple pregnancy rate in double blastocyst transplantation group was significantly higher than that in single blastocyst transplantation group (52.6 vs 2.4%) (P0.001), and the implantation rate in single blastocyst transplantation group was significantly higher than that in double blastocyst transplantation group (79.2 vs. 57.5%) (P0.001). The gestational age and average birth weight of single blastocyst transplantation group were significantly higher than those of double blastocyst transplantation group [(38.6 卤2.1) weeks vs (37.4 卤2.4) weeks, (3 282.0 卤523.4) g vs. (2 937.9 卤645.5) g] (P0.001). Conclusion D5 single blastocyst transplantation can be recommended for 35 years old patients with normal ovarian reserve, fresh cycle and D5 blastocyst transplantation in the first resuscitation cycle, and the living rate of D5 single blastocyst transplantation is similar to that of D5 double blastocyst transplantation. It can significantly reduce the rate of multiple births, prolong the gestational age and improve the birth weight of the newborn.
【作者单位】：中山大学附属第六医院生殖医学研究中心;
【基金】：国家自然科学基金(81070495)
【分类号】：R714.8

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