血浆中LncRNA GAS5在多囊卵巢综合征合并胰岛素抵抗患者中的表达及意义

发布时间：2018-07-04 14:06

本文选题：多囊卵巢综合征 + 胰岛素抵抗　；参考：《广东医学》2017年21期

【摘要】：目的初步探索LncRNA GAS5与多囊卵巢综合征(PCOS)胰岛素抵抗的关系,为PCOS分子机制研究提供新思路。方法收集合并胰岛素抵抗的PCOS不孕患者(PCOS组)和单纯输卵管因素不孕或男方因素非PCOS患者(非PCOS组)外周血标本各30例及相应临床病例资料,比较分析两组患者临床相关指标如BMI、空腹血糖、胰岛素、HOMA-IR等,以及血清中LncRNA GAS5的表达水平。结果 HOMA-IR在两组间比较差异无统计学意义(P0.05),但PCOS组平均HOMA-IR指数为5.85,高于非PCOS组;PCOS组空腹血糖明显高于非PCOS组(P=0.000);PCOS组患者血浆中IL-18浓度要明显高于非PCOS组(P0.000 1);PCOS组血浆中LncRNA GAS5表达要明显低于非PCOS组(P0.000 1),GAS5的表达与HOMA-IR呈负相关(P=0.003 5,r=0.515 6)。结论 PCOS组LncRNA GAS5明显下调,而且GAS5低表达和胰岛素抵抗有密切关系,LncRNAGAS5的低表达有可能是PCOS发生和进展的一个重要因素。
[Abstract]:Objective to explore the relationship between LncRNA GAS5 and insulin resistance in polycystic ovary syndrome (PCOS). Methods the peripheral blood samples of 30 PCOS infertile patients with insulin resistance (PCOS group) and 30 infertile patients with simple tubal factor or male factor (non-PCOS group) were collected and the corresponding clinical data were collected. The clinical parameters such as BMI, fasting blood glucose, insulin and HOMA-IR, and the expression of LncRNA GAS5 in serum were compared between the two groups. Results there was no significant difference in HOMA-IR between the two groups (P0.05), but the average HOMA-IR index in PCOS group was 5.85, which was significantly higher than that in PCOS group (P0.000) and PCOS group (P0.000). The expression of GAS5 in middle LncRNA was significantly lower than that in non-PCOS group (P0.000 1). There was a negative correlation between the expression of GAS5 and HOMA-IR (P0. 003 5 rn + 0. 515 6). Conclusion LncRNA GAS5 is down-regulated in PCOS group, and the low expression of GAS5 and insulin resistance may be an important factor in the pathogenesis and progression of PCOS.
【作者单位】：中山大学孙逸仙纪念医院生殖中心;中山大学中山医学院医学检验系;中山大学中山医学院临床医学系;
【基金】：广东省自然科学基金资助项目(编号:2015A030313054) 2015年中山大学医科暑期学生科研项目(编号:54)
【分类号】：R711.75

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