舒芬太尼替代芬太尼应用于分娩镇痛的安全性分析

发布时间：2018-07-07 12:23

本文选题：舒芬太尼 + 无痛分娩　；参考：《中国微创外科杂志》2017年07期

【摘要】：目的探讨舒芬太尼替代芬太尼在无痛分娩应用的安全性和可行性。方法将2014年8月-2016年2月在我院接受自然生产的初产妇300例,按患者入院的先后顺序及意愿选择分娩方式分为芬太尼组、舒芬太尼组和对照组3组,每组100例。对照组自然生产,芬太尼组、舒芬太尼组分别采用芬太尼和舒芬太尼无痛分娩,产程若出现宫缩乏力加滴缩宫素。观察总产程时间,视觉模拟评分(visual analogue scale,VAS)进行疼痛评分,并发症,新生儿Apgar 1、10 min评分。结果总产程时间对照组明显短于芬太尼组[(402.8±81.9)min vs.(476.5±84.8)min,q=9.185,P0.05];疼痛VAS评分舒芬太尼组、芬太尼组明显低于对照组[(3.0±0.7)分vs.(7.1±0.7)分,q=58.571,P0.05;(3.3±0.7)分vs.(7.1±0.7)分,q=54.286,P0.05]。3组产后并发症发生率无统计学差异(χ~2=0.150,P=0.928)。3组新生儿Apgar 1、10 min评分有统计学差异(P0.05),但都在8分以上,差异无实际临床意义。结论舒芬太尼应用于无痛分娩时联合缩宫素能获得满意的镇痛效果,安全有效。
[Abstract]:Objective to investigate the safety and feasibility of sufentanil replacing fentanyl in painless delivery. Methods from August 2014 to February 2016, 300 primiparas who were given birth in our hospital were divided into three groups: fentanyl group, sufentanil group and control group, 100 cases in each group. Control group, fentanyl group and sufentanil group were given fentanyl and sufentanil painless delivery respectively. The total duration of labor, visual analogue score (visual analogue scale), pain score, complications and neonatal Apgar 1 + 10 min score were observed. Results the total duration of labor in the control group was significantly shorter than that in the fentanyl group [(402.8 卤81.9) min vs. (卤84.8) min, P 0.05], and the pain score in sufentanil group was significantly lower than that in the fentanyl group. The incidence of postpartum complications in fentanyl group was significantly lower than that in control group [(3.0 卤0.7) scores vs. (7.1 卤0.7) scores vs 58.571g P0.05; (3.3 卤0.7) scores vs 54.286p0.05] .3, there was no statistical difference in the incidence of postpartum complications (蠂 2 0.150 P 0.928). Conclusion Sufentanil combined with oxytocin in painless delivery can obtain satisfactory analgesic effect and is safe and effective.
【作者单位】：郑州大学附属洛阳中心医院麻醉科;新乡医学院第一附属医院麻醉科;
【分类号】：R714.3

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