益生菌联合小麦纤维素对妊娠晚期孕妇肠道微生物的影响

发布时间：2018-07-10 17:57

本文选题：益生菌 + 小麦纤维素　；参考：《中华医院感染学杂志》2015年15期

【摘要】：目的观察益生菌联合小麦纤维素对妊娠晚期便秘孕妇肠道微生物的影响,并探讨其可能机制。方法收集2012年3月-2013年10月156例妊娠晚期便秘孕妇,随机分成对照组和治疗组,每组各78例,对照组仅给予常规综合治疗,治疗组在相同常规综合治疗的基础上给予口服益生菌联合小麦纤维素治疗,在治疗前1d及治疗2周后分别检测并比较两组孕妇肠道微生物的变化,同时比较两组疗效,数据采用SPSS 16.0软件进行分析。结果治疗组孕妇治疗前乳杆菌属及肠球菌属的菌落数分别为(8.29±0.71)CFU/g及(10.26±1.12)CFU/g,治疗后分别为(9.35±0.82)CFU/g及(11.33±1.21)CFU/g,治疗后均较治疗前显著增加(P0.01);治疗组孕妇酵母样真菌菌落数治疗前为(4.13±0.53)CFU/g、治疗后为(3.53±0.44)CFU/g,治疗后较治疗前明显降低,亦较对照组治疗后明显降低(P0.01)。结论在常规综合治疗的基础上,益生菌联合小麦纤维素可增加妊娠晚期合并便秘孕妇肠道乳杆菌属等益生菌,维持肠道微生态平衡,增加妊娠晚期便秘治疗的有效率,临床疗效确切,并安全可靠。
[Abstract]:Objective to observe the effect of probiotics combined with wheat cellulose on intestinal microorganism in pregnant women with constipation in late pregnancy and to explore its possible mechanism. Methods 156 pregnant women with late pregnancy constipation from March 2012 to October 2013 were randomly divided into control group and treatment group with 78 cases in each group. The treatment group was treated with oral probiotics combined with wheat cellulose on the basis of the same routine comprehensive therapy. The changes of intestinal microbes in pregnant women were detected and compared 1 day before treatment and 2 weeks after treatment, and the efficacy of the two groups was compared. The data were analyzed by SPSS 16.0 software. Results the colonies of Lactobacillus and Enterococcus in the treatment group were (8.29 卤0.71) CFU / g and (10.26 卤1.12) CFU / g respectively, and (9.35 卤0.82) CFU / g and (11.33 卤1.21) CFU / g after treatment, respectively, which were significantly increased after treatment (P0.01), and the number of yeast like fungi colonies in the treatment group was (4.13 卤0.53) CFU / g before treatment, and was (4.13 卤0.53) CFU / g before treatment in the treatment group, and (9.35 卤0.82) CFU / g and (11.33 卤1.21) CFU / g after treatment respectively (P0.01). After treatment, it was (3.53 卤0.44) CFU / g, which was significantly lower than that before treatment. It was also significantly lower than that in the control group (P0.01). Conclusion on the basis of routine comprehensive therapy, probiotics combined with wheat cellulose can increase the number of probiotics of Lactobacillus in the intestine of pregnant women with constipation, maintain the balance of intestinal microecology, and increase the effective rate of constipation treatment in late pregnancy. The clinical curative effect is accurate, and safe and reliable.
【作者单位】：绍兴市妇幼保健院生殖健康科;
【基金】：浙江省人口计生委科研基金资助项目(JSW2012-B019)
【分类号】：R714.255

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