抗病毒治疗在HIV感染孕妇母婴阻断中的疗效及安全评估

发布时间：2018-07-10 18:25

本文选题：艾滋病病毒 + 抗病毒治疗　；参考：《中国艾滋病性病》2017年02期

【摘要】：目的探讨抗病毒治疗在艾滋病病毒(HIV)感染孕妇母婴阻断中的疗效性及安全性,为临床IIV感染孕妇母婴阻断治疗提供参考依据。方法收集2010年1月至2016年1月于深圳市第三人民医院分娩的HIV感染孕妇109例,根据不同抗病毒治疗方案将其分为二组:抗病毒治疗组(ART)与对照组(未正规治疗组)。两组新生儿均给予人工喂养。对比两组孕妇分娩情况、新生儿出生情况及HIV感染情况。采用SPSS 19.0软件对数据进行统计分析。结果 ART组共91例,其中86例剖宫产,5例经阴道分娩,新生儿HIV感染率为0,1年存活率为100%;对照组18例均剖宫产分娩,新生儿HIV感染率3/18,1年内2例发生感染HIV死亡,两组孕妇的分娩方式、分娩结局及新生儿HIV感染率,差异有统计学意义(P0.05);两组新生儿低出生体重率、早产率差异无统计学意义(P0.05)。109名新生儿无一名出现窒息和畸形。结论 ART在阻断母婴传播中的疗效是显著的,可有效降低胎儿或新生儿的HIV感染率,孕14周后采用ART对胎儿相对安全。
[Abstract]:Objective to investigate the efficacy and safety of antiviral therapy in pregnant women with HIV infection. Methods 109 pregnant women with HIV infection who were delivered in Shenzhen third people's Hospital from January 2010 to January 2016 were divided into two groups according to different antiviral treatment schemes: the antiviral treatment group (art) and the control group (non-regular treatment group). Both groups were given artificial feeding. The delivery, newborn and HIV infection were compared between the two groups. The data were analyzed by SPSS 19.0 software. Results in art group, there were 91 cases, including 86 cases of cesarean delivery, 5 cases of vaginal delivery, the rate of neonatal HIV infection was 0, the 1 year survival rate was 100%, the control group 18 cases were cesarean section delivery, the neonatal HIV infection rate was 3 / 18, 2 cases died of HIV infection within 1 year. There were significant differences in delivery style, delivery outcome and neonatal HIV infection rate between the two groups (P0.05); there was no significant difference in low birth weight rate and premature delivery rate between the two groups (P0.05) .109 newborns had no asphyxia and malformation. Conclusion art is effective in blocking mother-to-child transmission and can effectively reduce the infection rate of HIV in fetus or newborn. Art is relatively safe for fetus after 14 weeks of gestation.
【作者单位】：深圳市第三人民医院;
【基金】：深圳市卫生计生系统科研项目(201402038)~~
【分类号】：R714.251

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