女性不孕症患者血清及宫颈黏液中自身抗体检测对病情的评估价值

发布时间：2018-07-11 13:43

本文选题：不孕症 + 自身抗体　；参考：《中国现代医学杂志》2016年22期

【摘要】：目的分析女性不孕症患者血清及宫颈黏液中自身抗体检测对病情的评估价值。方法选取2012年7月-2014年7月间至该院接受检查的女性不孕患者138例作为观察组对象。另取同期在该院因宫颈炎症接受检查的已育女性106例作为对照组。比较两组研究对象的血清及宫颈黏液自身抗体水平、外周血调解性T细胞(Treg)水平,进一步分析观察组患者中自身抗体与Treg水平的相关性。结果 1观察组患者的血清及宫颈黏液中抗精子抗体(AsAb)、抗卵巢抗体(AoAb)、抗人绒毛膜促性腺激素(AhCGAb)、抗子宫内膜抗体(EMAb)、甲状腺自身抗体(ATA)、抗-β-2糖蛋白1抗体(α-β-2GP1)水平高于对照组女性(P0.05);2观察组患者的外周血Treg水平低于对照组(P0.05);3不孕症女性血清及宫颈黏液中的AsAb、AoAb、AhCGAb、EMAb、ATA、α-β-2GP1等自身抗体水平与外周血Treg水平呈负相关(P0.05)。结论女性不孕症患者血清及宫颈黏液中自身抗体水平大幅上升,与患者的疾病发生发展以及病情严重程度均关系密切,是临床诊断及指导治疗的理想指标。
[Abstract]:Objective to analyze the evaluation value of autoantibodies in serum and cervical mucus of female infertility patients. Methods 138 infertile women from July 2012 to July 2014 were selected as observation group. Another 106 pregnant women who were examined for cervix inflammation in the same period were taken as control group. The levels of serum and cervical mucus autoantibodies and peripheral blood mediating T cells (Treg) were compared between the two groups, and the correlation between autoantibodies and Treg levels in the observation group was further analyzed. Results 1 the levels of anti-sperm antibody, (AsAb), anti-ovary antibody, (AoAb), anti-human chorionic gonadotropin (AhCGAb), anti-endometrial antibody (Emab), thyroid autoantibody (ATA) and anti-尾 -2 glycoprotein 1 antibody (伪-尾 -2GP1) in serum and cervical mucus of the observation group were higher than those in the control group. The level of Treg in peripheral blood of control group (P0.05) was lower than that of control group (P0.05). Conclusion the level of autoantibodies in serum and cervical mucus of female infertile patients is significantly increased, which is closely related to the occurrence and development of the disease and the severity of the disease. It is an ideal index for clinical diagnosis and treatment.
【作者单位】：河北大学附属医院妇科;河北省望都县医院妇产科;
【分类号】：R711.6

【相似文献】