老年宫颈鳞癌组织中亮氨酸拉链肿瘤抑制基因1和Survivin的表达及意义

发布时间：2018-07-12 20:04

本文选题：宫颈鳞癌 + 亮氨酸拉链肿瘤抑制基因(FEZ)　；参考：《中国老年学杂志》2017年18期

【摘要】：目的检测老年人子宫鳞癌中亮氨酸拉链肿瘤抑制基因(FEZ)1和生存素(Survivin)的表达,探讨二者的关系及临床意义。方法宫颈鳞癌老年患者59例为观察组,23例因子宫脱垂切除的全子宫中非肿瘤性的宫颈组织为对照组,应用免疫组化SP法检测两组中FEZ1和Survivin的表达,分析其表达特征及相关性。结果两组FEZ1和Survivin表达的阳性率差异有统计学意义(P0.01)。观察组中FEZ1和Survivin表达阳性率与肿瘤的最大径、宫旁浸润密切相关;Survivin表达阳性率与肿瘤淋巴结转移密切相关。观察组中FEZ1和Survivin表达无相关性。结论 FEZ1低表达、Survivin高表达是促进老年人宫颈鳞癌形成的因素,二者参与肿瘤进展。FEZ1和Survivin无明显协同作用。
[Abstract]:Objective to detect the expression of leucine zipper tumor suppressor gene (FEZ) 1 and survivin (survivin) in the elderly uterine squamous cell carcinoma and to explore the relationship between them and their clinical significance. Methods the expression of FEZ1 and survivin was detected by immunohistochemical SP method in 23 cases of cervical tissues without tumor after hysterectomy with uterine prolapse. The expression of FEZ1 and survivin in the two groups were analyzed by immunohistochemical SP method. The expression of FEZ1 and survivin in the two groups were analyzed. Results the positive rates of FEZ 1 and survivin in the two groups were significantly different (P 0.01). The positive rate of FEZ1 and survivin was closely related to the maximum diameter of tumor, and the expression rate of survivin was closely related to lymph node metastasis. There was no correlation between FEZ1 and survivin expression in the observation group. Conclusion the low expression of FEZ1 and the high expression of survivin are the factors that promote the formation of cervical squamous cell carcinoma in the elderly. There is no significant synergistic effect between FEZ1 and survivin in tumor progression.
【作者单位】：锦州市妇婴医院妇科;锦州医科大学附属第一医院妇产科;
【分类号】：R737.33

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