产前监测血清脂氧素A4和热休克蛋白70水平对诊断子痫前期的临床价值

发布时间：2018-07-16 14:00

【摘要】：目的探讨产前监测血清脂氧素A4(LXA4)、热休克蛋白70(HSP70)水平对诊断子痫前期的临床价值。方法选取2014年6月-2016年7月在该院产科行产前检查并住院分娩的单胎妊娠孕妇128例。其中,发生子痫前期的60例孕妇作为观察组,包括:轻度子痫前期组27例,早发型重度子痫前期组20例,晚发型重度子痫前期组13例。正常妊娠的68例孕妇作为对照组。分娩前抽取空腹血,采用酶联免疫吸附测定法(ELISA)检测各组孕妇血清中LXA4、HSP70表达水平,并进行对比分析。结果轻度及重度子痫前期组孕妇血清LXA4水平均低于对照组,差异有统计学意义(P0.05),且轻度子痫前期组孕妇血清LXA4水平高于重度子痫前期组(P0.05),早发型重度子痫前期组孕妇血清LXA4水平与晚发型重度子痫前期组比较,差异无统计学意义(P0.05);轻度及重度子痫前期组孕妇血清HSP70水平均高于对照组,差异有统计学意义(P0.05),轻度子痫前期组孕妇血清HSP70水平低于重度子痫前期组(P0.05)。结论子痫前期患者产前血清LXA4水平降低、HSP70水平升高,且疾病程度越重,血清LXA4水平越低、HSP70水平越高,联合监测血清LXA4、HSP70水平对诊断子痫前期具有较高的应用价值。
[Abstract]:Objective to investigate the clinical value of prenatal monitoring of serum lipoxygen-A _ 4 (LXA _ 4) and heat shock protein 70 (HSP70) levels in the diagnosis of preeclampsia. Methods 128 pregnant women with single pregnancy were selected from June 2014 to July 2016. Among them, 60 pregnant women with preeclampsia were treated as observation group, including 27 cases of mild preeclampsia group, 20 cases of early severe preeclampsia group and 13 cases of late severe preeclampsia group. 68 normal pregnant women served as control group. Fasting blood samples were collected before delivery and the expression of LXA4HSP70 in serum of pregnant women in each group was detected by enzyme-linked immunosorbent assay (Elisa). Results Serum LXA4 levels in mild and severe preeclampsia group were lower than those in control group. The serum LXA4 level of mild preeclampsia group was higher than that of severe preeclampsia group (P0.05), and the serum LXA4 level of early onset severe preeclampsia group was higher than that of late onset severe preeclampsia group. The level of serum HSP70 in mild and severe preeclampsia group was higher than that in control group (P0.05). The serum HSP70 level in mild preeclampsia group was lower than that in severe preeclampsia group (P0.05). Conclusion the level of serum LXA4 in pre-eclampsia patients decreased and the level of HSP70 increased, and the more serious the disease, the lower the level of serum LXA4 and the higher the level of HSP70. The combined monitoring of serum LXA4 HSP70 level is of great value in the diagnosis of preeclampsia.
【作者单位】：河北医科大学第四医院妇产科;河北医科大学研究生院;河北石家庄市长安区阜康社区卫生服务中心中医科;
【分类号】：R714.244

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