孕期人乳头状瘤病毒感染类型与母婴传播的前瞻性研究

发布时间：2018-07-21 11:19

【摘要】：目的探讨人乳头状瘤病毒(HPV)感染类型及母婴传播率,指导临床预防感染。方法回顾性分析2012年1月-2014年1月产前检查HPV的2 132例孕妇临床资料,根据孕妇及新生婴儿的资料及快速核酸分子导流法检测人乳头瘤病毒分型,分析孕期HPV感染分型、母婴传播率。结果 2 132例孕妇中HPV感染280例,感染率为13.13%;年龄22、22~24、25~27、28~30、31~33岁及≥34岁的孕妇感染率分别为8.89%、10.17%、12.68%、13.32%、13.88%、16.09%;感染孕妇中HPV高危型251例占89.64%,其中16、52、58型的孕妇分别为51、48、33例,其他高危型119例;HPV低危型孕妇29例;280例HPV感染孕妇产的新生儿中,HPV感染的新生儿63例,母婴垂直传播率22.5%;新生儿HPV高危型54例、低危型9例,分别占85.71%、14.29%;280例HPV感染孕妇中,经阴道产新生儿143例,33例有HPV感染,感染率23.08%;经剖宫产新生儿137例,30例有HPV感染,感染率21.09%。结论孕妇HPV感染率与年龄无显著相关性,孕期感染的HPV多为高危型,新生儿与孕妇感染的HPV分型较为一致,但母婴垂直传播与分娩方式无相关性,孕期HPV的筛查对于预防宫颈癌等恶性病变,以及尽早发现新生儿HPV感染有重要意义,值得临床推广应用。
[Abstract]:Objective to investigate the types of human papillomavirus (HPV) infection and the rate of mother-to-child transmission, and to guide clinical prevention of human papillomavirus (HPV) infection. Methods the clinical data of 2 132 pregnant women who underwent prenatal examination for HPV from January 2012 to January 2014 were retrospectively analyzed. According to the data of pregnant women and newborn infants and the rapid nucleic acid molecular diversion method, HPV typing was detected and the types of HPV infection during pregnancy were analyzed. Mother-to-child transmission rate Results among 2 132 pregnant women, 280 cases were infected with HPV, the infection rate was 13.1313; the infection rate of pregnant women aged 22 2222 / 252728 / 3031 / 33 and older than 34 was 8.89 / 10.1710.1712.68 / 13.32 / 13.88 and 16.09, respectively; among the pregnant women with infection, 251 cases were high risk type HPV (89.6464), among which the pregnant women with 165258 type were 51 / 4833, respectively. Among the 280 newborns with HPV infection, 63 cases were infected with HPV-infected neonates, and the mother-to-child vertical transmission rate was 22.5.The high risk type and low risk type of newborns were 54 cases and 9 cases respectively, accounting for 85.71% of the 280 cases of HPV infection. The infection rate of HPV was 23.08 in 143 newborns with vaginal delivery and 30 in 137 newborns by cesarean section, and the infection rate was 21.09%. Conclusion there is no significant correlation between the infection rate of HPV in pregnant women and age. The HPV type of infection in pregnant women is high risk type. The types of HPV infection in newborns and pregnant women are consistent, but there is no correlation between vertical transmission from mother to child and delivery mode. The screening of HPV during pregnancy is of great significance for the prevention of malignant lesions such as cervical cancer and the early detection of HPV infection in newborns, which is worthy of clinical application.
【作者单位】：南通市妇幼保健院产科;
【基金】：江苏省科技厅研究基金资助项目(JS2013-08934)
【分类号】：R714.251

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