人乳头瘤病毒基因分型检测在30岁以下年轻妇女宫颈病变中的应用价值

发布时间：2018-07-24 07:51

【摘要】：目的探讨人乳头瘤病毒(human papillomavirus,HPV)基因分型检测在30岁以下年轻妇女宫颈病变中的应用价值,为年轻妇女宫颈病变筛查提供依据。方法选取985例30岁以下年轻妇女,通过病理学或细胞学检测分为体检组、疣状病变组、宫颈炎性病变组、宫颈上皮内瘤样病变组及宫颈癌组,采用人乳头瘤病毒基因分型检测方法进行分析,其中包括13种高危型HPV(16、18、31、33、35、39、45、51、52、56、58、59、68),5种低危型HPV(6、11、42、43、44)和3种中国人常见的基因型HPV(53、66和CP8304)。结果 HPV总检出率为21.42%(211/985),其中高危型检出率为25.38%(250/985),低危型检出率为3.76%(37/985),多重感染占24.17%,宫颈上皮内瘤样病变与宫颈癌组同体检组相比较,差异有统计学有意义(P0.05)。结论年轻妇女HPV-DNA检测非常重要,对发现宫颈癌及癌前病变很有价值。
[Abstract]:Objective to investigate the value of human papillomavirus genotyping in cervical lesions of young women under 30 years of age, and to provide evidence for screening cervical lesions in young women. Methods 985 young women under 30 years of age were divided into three groups by pathological or cytological examination: physical examination group, verrucous lesion group, cervical inflammatory lesion group, cervical intraepithelial neoplasia group and cervical carcinoma group. The genotyping analysis of human papillomavirus (HPV) was carried out, including 13 types of high-risk HPV (16 / 18 / 31A / 33N / 39C / 451C / 51C / 51C / 51C / 52C / 585968) and 5 low risk HPV (6A111142C4344) and 3 genotypes of HPV (53m66 and CP8304) commonly found in Chinese. Results the total detection rate of HPV was 21.42% (211 / 985), of which the high risk type was 25.38% (250 / 985), the low risk type was 3.76% (37 / 985), and the multiple infection was 24.17%. There was a significant difference between the cervical intraepithelial neoplasia group and the cervical cancer group (P0.05). Conclusion the detection of HPV-DNA in young women is very important and valuable in the detection of cervical cancer and precancerous lesions.
【作者单位】：首都医科大学附属北京天坛医院检验科;北京市免疫试剂临床工程技术研究中心;
【基金】：北京市卫生系统高层次卫生技术人才培养项目(2013-3-052)~~
【分类号】：R737.33;R440

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