r-hCG基础上添加u-hCG与否对ICSI-ET临床结局的影响

发布时间：2018-07-24 09:22

【摘要】：目的：探讨ICSI助孕周期扳机时单用r-hCG或联合u-hCG，与获卵、受精、胚胎情况、妊娠结局的关系，初步了解r-hCG基础上添加u-hCG是否影响周期结局，，以指导临床工作。材料与方法：回顾性分析2011年6月1日～2013年5月31日在广西医科大学第一附属医院接受长方案ICSI-ET的143个周期，年龄25～34岁，获卵4～20个。扳机日分别使用r-hCG250μg（88个周期）与r-hCG250μg+u-hCG2000～5000IU（55个周期），分别比较两组间获卵、受精、胚胎情况以及妊娠结局。实验结果用SPSS16.0软件包分析，P＜0.05为有统计学意义。结果：1、扳机用药存在病例选择偏倚，单用r-hCG组降调后窦卵泡个数多，Gn启动量及总量少，OHSS发生风险大（P均＜0.05）。2、分层后，当降调后月经第2天的窦卵泡数＞15个，或10～15个时，一般情况无统计学差异，组间熟卵率、正常受精率、正常卵裂率、可用胚率、优胚率无统计学差异，种植率、临床妊娠率、早期流产率及活产率无统计学差异。结论：25～34岁，BMI正常、卵巢反应正常的女性，当降调后窦卵泡数≥10个时，r-hCG250μg基础上增用u-hCG2000～5000IU扳机，未提高卵子成熟率、正常受精率、正常卵裂率、可移植胚胎率、优胚率，未改善妊娠结局。
[Abstract]:Objective: to investigate the relationship between single use of r-hCG or u-hCGin in ICSI assisted pregnancy cycle trigger and oocyte acquisition, fertilization, embryo status and pregnancy outcome, and to understand whether the addition of u-hCG on the basis of r-hCG could influence the cycle outcome, so as to guide the clinical work. Materials and methods: from June 1, 2011 to May 31, 2013, 143 cycles of ICSI-ET were performed in the first affiliated Hospital of Guangxi Medical University, aged 25 to 34 years. R-hCG250 渭 g (88 cycles) and r-hCG250 渭 g u-hCG2000~5000IU (55 cycles) were used on the trigger day to compare the egg acquisition, fertilization, embryo status and pregnancy outcome between the two groups. The results were analyzed by SPSS16.0 software package (P < 0. 05). Results in the r-hCG group, there was a greater risk of occurrence of OHSS (P < 0. 05). After stratification, the number of antral follicles was more than 15, or 10 ~ 15, when the second day of menstruation was adjusted. There was no statistical difference in general conditions. There was no statistical difference in maturing egg rate, normal fertilization rate, normal cleavage rate, usable embryo rate, excellent embryo rate, implantation rate, clinical pregnancy rate, early abortion rate and live birth rate. Conclusion in women with normal BMI and normal ovarian response, when the number of antral follicles is more than 10, the u-hCG2000~5000IU trigger can not increase the maturation rate, the normal fertilization rate, the normal cleavage rate, the transferable embryo rate, the excellent embryo rate, the normal fertilization rate, the normal cleavage rate, the rate of transferable embryos, and the optimal embryo rate. The pregnancy outcome was not improved.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.8

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