同步放化疗治疗Ib2和IIa2期宫颈癌疗效及预后相关因素分析
发布时间：2018-07-26 06:53
【摘要】：目的:探讨同步放化疗治疗Ib2期和IIa2期宫颈癌的疗效和不良反应,并分析预后影响因素。方法:回顾分析2000年1月至2010年12月首都医科大学附属北京妇产医院妇瘤科收治的73例接受同步放化疗的Ib2和IIa2期宫颈癌患者的临床病理资料。统计有效率和疾病控制率评价近期疗效,统计3年、5年无瘤生存率(DFS)及总生存率(OS)评价远期疗效,记录患者的不良反应,并分析可能影响患者预后的相关因素。结果:同步放化疗治疗Ib2期和IIa2期宫颈癌的有效率(CR+PR)为91.78%,疾病控制率(CR+PR+SD)为97.26%;3年DFS为84.93%,0S为86.30%;5年DFS为79.45%,0S为82.19%。所有不良反应患者均可耐受,对症治疗后均可缓解。单因素分析显示,患者的生存率与肿瘤的病理类型、分化程度、大小、有无淋巴结转移以及治疗前后血鳞状细胞癌抗原(SCC-Ag)值有关(P0.05)。多因素分析表明,肿瘤病理类型、大小、有无淋巴结转移及治疗后1个月血SCC-Ag值为远期疗效的独立影响因素。结论:同步放化疗治疗Ib2期和IIa2期宫颈癌的近、远期疗效肯定,不良反应可耐受,是一种可供选择的方法。病理类型为腺癌、肿瘤直径㧐5cm、有淋巴结转移、治疗后1个月血SCC-Ag值≥1.5ng/ml者预后较差,需进一步加强研究。
[Abstract]:Objective: to investigate the efficacy and side effects of simultaneous radiotherapy and chemotherapy in Ib2 and IIa2 cervical cancer and to analyze the prognostic factors. Methods: the clinicopathological data of 73 patients with Ib2 and IIa2 cervical cancer who received concurrent radiotherapy and chemotherapy from January 2000 to December 2010 were retrospectively analyzed. Effective rate and disease control rate were used to evaluate the short-term curative effect, the 3-year, 5-year tumor-free survival rate (DFS) and the overall survival rate (OS) were used to evaluate the long-term efficacy. The adverse reactions were recorded, and the related factors affecting the prognosis of the patients were analyzed. Results: the effective rate of concurrent radiotherapy and chemotherapy for Ib2 and IIa2 cervical carcinoma was 91.78, the disease control rate (CR PR SD) was 97.260.The DFS for 3 years was 84.93s and 86.30, and the DFS for 5 years was 79.450S and 82.19S. All adverse reactions can be tolerated and alleviated after symptomatic treatment. Univariate analysis showed that survival rate was related to pathological type, differentiation, size, lymph node metastasis and SCC-Ag before and after treatment (P0.05). Multivariate analysis showed that tumor pathological type, size, lymph node metastasis and blood SCC-Ag value 1 month after treatment were independent factors of long-term curative effect. Conclusion: simultaneous radiotherapy and chemotherapy is an alternative method for the treatment of Ib2 and IIa2 cervical cancer. The pathological type was adenocarcinoma with a diameter of 5 cm and lymph node metastasis. One month after treatment, the prognosis of patients with SCC-Ag 鈮，
本文编号：2145209
[Abstract]:Objective: to investigate the efficacy and side effects of simultaneous radiotherapy and chemotherapy in Ib2 and IIa2 cervical cancer and to analyze the prognostic factors. Methods: the clinicopathological data of 73 patients with Ib2 and IIa2 cervical cancer who received concurrent radiotherapy and chemotherapy from January 2000 to December 2010 were retrospectively analyzed. Effective rate and disease control rate were used to evaluate the short-term curative effect, the 3-year, 5-year tumor-free survival rate (DFS) and the overall survival rate (OS) were used to evaluate the long-term efficacy. The adverse reactions were recorded, and the related factors affecting the prognosis of the patients were analyzed. Results: the effective rate of concurrent radiotherapy and chemotherapy for Ib2 and IIa2 cervical carcinoma was 91.78, the disease control rate (CR PR SD) was 97.260.The DFS for 3 years was 84.93s and 86.30, and the DFS for 5 years was 79.450S and 82.19S. All adverse reactions can be tolerated and alleviated after symptomatic treatment. Univariate analysis showed that survival rate was related to pathological type, differentiation, size, lymph node metastasis and SCC-Ag before and after treatment (P0.05). Multivariate analysis showed that tumor pathological type, size, lymph node metastasis and blood SCC-Ag value 1 month after treatment were independent factors of long-term curative effect. Conclusion: simultaneous radiotherapy and chemotherapy is an alternative method for the treatment of Ib2 and IIa2 cervical cancer. The pathological type was adenocarcinoma with a diameter of 5 cm and lymph node metastasis. One month after treatment, the prognosis of patients with SCC-Ag 鈮，
本文编号：2145209
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