随机尿微量白蛋白与尿肌酐比值在妊娠高血压疾病早期肾损伤的临床应用
发布时间：2018-07-27 21:27
【摘要】：目的:探讨随机尿微量白蛋白与尿肌酐比值(UACR)在妊娠高血压疾病早期肾损伤中的应用价值,制定轻度和重度子痫前期(PE)的随机UACR参考值。方法:选取2013年1月至2014年7月在我院住院的妊娠期高血压疾病患者148例(妊娠期高血压48例,轻度PE患者55例,重度PE患者45例),正常晚孕期孕妇30例,测定随机UACR、24h尿蛋白定量,进行相关性分析。应用受试者工作曲线,确定UACR对应于24h尿蛋白0.3g及2.0g时的诊断界值。结果:妊娠期高血压组、轻度PE组、重度PE组及正常晚孕组的平均24h尿蛋白分别为(114.91±52.31)mg/24h、(779.12±540.85)mg/24h、(4159.55±1719.69)mg/24h、(80.05±29.68)mg/24h,随机UACR分别为(16.91±7.76)mg/mmol、(75.20±38.10)mg/mmol、(486.78±202.73)mg/mmol、(1.42±0.45)mg/mmol。妊娠期高血压组的24h尿蛋白定量与正常晚孕组比较,无显著差异(P0.05),其余各组两两比较差异均有统计学意义(P0.05);各组的随机UACR比较,差异均有统计学意义(P0.05)。妊娠期高血压疾病患者的随机UACR与24h尿蛋白定量呈高度线性相关(r=0.929,P0.001)。24h尿蛋白定量为0.3g和2.0g时对应的随机UACR值分别为32.85mg/mmol和174.5mg/mmol。结论:随机UACR与24h尿蛋白定量有高度相关性,检测随机UACR可用于及早发现妊娠期高血压疾病的早期肾损伤;随机UACR有望代替24h尿蛋白定量作为判断妊娠高血压疾病病情严重程度的评估指标;随机UACR的最佳诊断界值需更大样本量的研究支持。
[Abstract]:Objective: to investigate the value of random urinary microalbumin to urinary creatinine ratio (UACR) in renal injury in the early stage of pregnancy-induced hypertension, and to establish the random UACR reference value for mild and severe preeclampsia (PE). Methods: 148 cases of hypertensive disorder complicating pregnancy (48 cases of hypertension complicating pregnancy, 55 cases of mild PE and 45 cases of severe PE) were selected from January 2013 to July 2014 in our hospital. The 24-hour urine protein of random UACRs was measured and the correlation was analyzed. Using the operating curve of subjects, the diagnostic threshold of UACR corresponding to 0.3 g and 2.0 g of 24 h urinary protein was determined. Results: the mean 24 h urinary protein levels in hypertensive complicating pregnancy group, mild PE group, severe PE group and normal late pregnancy group were (114.91 卤52.31) mg / r 24 h, (779.12 卤540.85) mg / r 24 h, (4159.55 卤1719.69) mg / r 24 h, (80.05 卤29.68) mg / r 24 h, and (16.91 卤7.76) mg / mol, (75.20 卤38.10) mg / mol, (486.78 卤202.73) mg / mol, (1.42 卤0.45) mg / mol, respectively. There was no significant difference in 24 hours urine protein between gestational hypertension group and normal late pregnancy group (P0.05), while the other two groups had statistical significance (P0.05); the random UACR of each group had statistical significance (P0.05). There was a high linear correlation between random UACR and 24-hour urinary protein quantification in hypertensive disorder complicating pregnancy (r = 0.929, P0.001). The corresponding random UACR values were 32.85mg/mmol and 174.5 mg / mmol. when 24h urinary protein quantification was 0.3 g and 2.0 g, respectively. Conclusion: there is a high correlation between random UACR and 24 hours urinary protein quantification. The detection of random UACR can be used to detect early renal injury in hypertensive disorder complicating pregnancy. Random UACR may be used as an index to evaluate the severity of pregnancy-induced hypertension in place of 24h urinary protein quantification, and the optimal diagnostic threshold of random UACR should be supported by a larger sample size.
【作者单位】： 广东省东莞市横沥医院妇产科;
【基金】：东莞市科技计划医疗卫生类科研一般项目(No:201310515000371)
【分类号】：R714.246
[Abstract]:Objective: to investigate the value of random urinary microalbumin to urinary creatinine ratio (UACR) in renal injury in the early stage of pregnancy-induced hypertension, and to establish the random UACR reference value for mild and severe preeclampsia (PE). Methods: 148 cases of hypertensive disorder complicating pregnancy (48 cases of hypertension complicating pregnancy, 55 cases of mild PE and 45 cases of severe PE) were selected from January 2013 to July 2014 in our hospital. The 24-hour urine protein of random UACRs was measured and the correlation was analyzed. Using the operating curve of subjects, the diagnostic threshold of UACR corresponding to 0.3 g and 2.0 g of 24 h urinary protein was determined. Results: the mean 24 h urinary protein levels in hypertensive complicating pregnancy group, mild PE group, severe PE group and normal late pregnancy group were (114.91 卤52.31) mg / r 24 h, (779.12 卤540.85) mg / r 24 h, (4159.55 卤1719.69) mg / r 24 h, (80.05 卤29.68) mg / r 24 h, and (16.91 卤7.76) mg / mol, (75.20 卤38.10) mg / mol, (486.78 卤202.73) mg / mol, (1.42 卤0.45) mg / mol, respectively. There was no significant difference in 24 hours urine protein between gestational hypertension group and normal late pregnancy group (P0.05), while the other two groups had statistical significance (P0.05); the random UACR of each group had statistical significance (P0.05). There was a high linear correlation between random UACR and 24-hour urinary protein quantification in hypertensive disorder complicating pregnancy (r = 0.929, P0.001). The corresponding random UACR values were 32.85mg/mmol and 174.5 mg / mmol. when 24h urinary protein quantification was 0.3 g and 2.0 g, respectively. Conclusion: there is a high correlation between random UACR and 24 hours urinary protein quantification. The detection of random UACR can be used to detect early renal injury in hypertensive disorder complicating pregnancy. Random UACR may be used as an index to evaluate the severity of pregnancy-induced hypertension in place of 24h urinary protein quantification, and the optimal diagnostic threshold of random UACR should be supported by a larger sample size.
【作者单位】： 广东省东莞市横沥医院妇产科;
【基金】：东莞市科技计划医疗卫生类科研一般项目(No:201310515000371)
【分类号】：R714.246
【共引文献】
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