子宫内膜癌组织中基因及分子标志物表达及其与预后的相关性研究

发布时间：2018-07-28 10:45

【摘要】：目的探讨子宫内膜癌组织中雌激素受体(ER)、孕激素受体(PR)、p53抑癌基因(p53)、抗原Ki-67(Ki-67)的表达及与临床预后之间的关系。方法选取2009—2014年广州医科大学附属第一医院妇科收治的79例子宫内膜癌患者的癌组织标本,采用免疫组化法检测其中ER、PR、p53、Ki-67的蛋白表达情况。结果 79例子宫内膜癌病例中,ER、PR、p53、Ki-67阳性表达率:87.3%、88.6%、84.8%、79.7%;ER的蛋白表达与患者预后有关;PR与病理类型、肌层浸润、组织分化有关;p53与组织分化有关;Ki-67与临床分期、淋巴转移有关(均P0.05)。ER与PR的表达、p53与Ki-67的表达均呈正相关(P0.05)。结论 ER、PR、p53、Ki-67的联合检测可能作为子宫内膜癌发生、发展及临床转移的生物学指标及作为判断子宫内膜癌恶性程度及评估预后的分子标志物,其具体作用机制值得进一步研究。
[Abstract]:Objective to investigate the expression of estrogen receptor (ER), progesterone receptor (PR) p53 tumor suppressor gene (p53) antigen Ki-67 (Ki-67) and its relationship with clinical prognosis in endometrial carcinoma. Methods 79 specimens of endometrial carcinoma were collected from the first affiliated Hospital of Guangzhou Medical University from 2009 to 2014, and the expression of ERPPRP53 Ki-67 was detected by immunohistochemical method. Results in 79 cases of endometrial carcinoma, the positive expression rate of p53 Ki-67 was: 87.3% and 88.6% and 84.810% respectively. The expression of ER protein was related to the prognosis of the patients. The expression of ER protein was related to the prognosis of the patients with PR and pathological type, infiltration of myometrium, tissue differentiation, p53 expression, tissue differentiation, Ki-67 and clinical stage. The expression of ER and PR was positively correlated with the expression of p53 and Ki-67 (P0.05). Conclusion the combined detection of p53 Ki-67 may be a biological marker for the occurrence, development and clinical metastasis of endometrial carcinoma, as well as a molecular marker for judging the malignant degree and evaluating the prognosis of endometrial carcinoma. The specific mechanism of the detection is worthy of further study.
【作者单位】：广州医科大学附属第一医院妇产科;
【分类号】：R737.33

【参考文献】