子宫肌瘤及子宫肌层中TGF-β3与FN表达的变化及意义

发布时间：2018-07-28 11:28

【摘要】：目的探讨子宫肌瘤及子宫肌层中转化生长因子(TGF)-β3与纤维连接蛋白(FN)表达的变化及意义。方法子宫肌瘤患者196例,其中绝经者96例,未绝经者100例,将绝经者根据肌瘤是否萎缩分成萎缩组40例及未萎缩组56例,采用免疫组化法检测并对比患者肌瘤组织和肌壁组织TGF-β3和FN的表达,应用放射免疫法检测并比较不同萎缩情况绝经患者的雌激素(E2)、孕激素(P)水平,分析绝经患者TGF-β3和FN与E2、P水平的相关性。结果绝经组肌瘤组织和肌壁组织TGF-β3评分均明显低于未绝经组肌瘤组织均明显高于同组肌壁组织(P0.05)。绝经组和未绝经组肌瘤组织及肌壁组织FN评分相比差异无统计学意义(P0.05)。萎缩组和未萎缩组肌瘤组织及肌壁组织TGF-β3、FN评分差异无统计学意义(P0.05),但两组肌瘤组织均明显高于同组肌壁组织(P0.05)。未萎缩组E2、P水平均明显高于萎缩组(P0.05)。依据Spearman法分析可知,绝经患者TGF-β3与E2、P水平均呈正相关(r=0.769,0.688;P=0.042,0.033),而绝经患者的FN与E2、P水平无关(r=0.106,0.211;P=0.228,0.159)。结论子宫肌瘤绝经患者TGF-β3表达较子宫肌层更高,且与E2、P水平密切相关,而FN无明显变化,临床可尝试通过监测TGF-β3水平以评估患者的疾病情况。
[Abstract]:Objective to investigate the expression of transforming growth factor (TGF)-尾 3 and fibronectin (FN) in uterine myoma and myometrium. Methods 196 patients with uterine leiomyoma were divided into atrophic group (n = 40) and unatrophic group (n = 56) according to the atrophy of leiomyoma, including 96 cases of menopause and 100 cases of unmenopause. The expressions of TGF- 尾 3 and FN in myoma and muscle wall were detected and compared by immunohistochemical method. The levels of estrogen (E2) and progesterone (P) in menopausal patients with different atrophy were detected and compared by radioimmunoassay. To analyze the correlation between TGF- 尾 3 and FN and E 2 P in menopausal patients. Results the score of TGF- 尾 3 in myoma tissue and muscle wall tissue in menopausal group was significantly lower than that in unmenopausal group (P0.05). There was no significant difference in FN score between menopausal group and unmenopausal group in myoma tissue and muscle wall tissue (P0.05). There was no significant difference in TGF- 尾 _ 3 FN score between the atrophy group and the non-atrophy group (P0.05), but the difference between the two groups was significantly higher than that in the same group (P0.05). The level of E 2 P in non atrophy group was significantly higher than that in non atrophy group (P 0.05). According to Spearman analysis, there was a positive correlation between TGF- 尾 _ 3 and E _ 2P levels in menopausal patients (r = 0.769 ~ 0.688), but there was no correlation between FN and E _ 2P level in postmenopausal patients (r = 0.106 ~ 0.211P ~ (0.2280.159). Conclusion the expression of TGF- 尾 3 in postmenopausal women with uterine leiomyoma is higher than that in myometrium and is closely related to the level of E2P, but FN has no obvious change.
【作者单位】：齐齐哈尔医学院附属第三医院妇一科;哈尔滨医科大学附属第二医院妇产科;
【基金】：黑龙江省卫生厅科研课题(No.2011-083)
【分类号】：R737.33

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