流产经历和子宫肌瘤家族史对子宫肌瘤患病风险的影响

发布时间：2018-07-29 07:48

【摘要】：目的探讨流产经历和子宫肌瘤家族史对子宫肌瘤患病风险的影响,为预防子宫肌瘤提出建议。方法采用病例-对照研究方法,使用结构式问卷调查的方式收集山东省城市和农村的10个县级单位20~65岁常住已婚已育女性的流产经历和子宫肌瘤家族史,同时收集其年龄、身高等信息。运用Logistic回归模型分析流产经历和子宫肌瘤家族史与子宫肌瘤的关系。应用交互作用的相对超额风险(RERI)、归因于交互作用的比例(AP)和协同指数(S)三个指标评价流产史和子宫肌瘤家族史的相加交互作用。结果多因素非条件Logistic回归模型结果显示,流产史(OR=1.39,95%CI:1.06~1.80)和子宫肌瘤家族史(OR=2.07,95%CI:1.36~3.15)均为子宫肌瘤的危险因素。流产史和子宫肌瘤家族史对子宫肌瘤患病风险存在相加交互作用(S=5.51,AP=0.59,RERI=2.14)。有子宫肌瘤家族史的研究对象,1次流产和2次以上流产经历其子宫肌瘤患病风险分别增加1.78倍和2.77倍,而无遗传背景的研究对象中,流产经历对子宫肌瘤发病影响较小。结论有子宫肌瘤遗传背景的敏感人群应注意计划怀孕,谨慎流产以降低患子宫肌瘤的风险。
[Abstract]:Objective to investigate the influence of abortion experience and family history of uterine leiomyoma on the risk of uterine leiomyoma. Methods A case-control study was conducted to collect the abortion experience and family history of uterine leiomyoma in 10 county units of Shandong Province, aged 20 to 65 years old, by means of structured questionnaire, and their ages were collected at the same time. Height, etc. Logistic regression model was used to analyze the relationship between abortion experience, family history of uterine leiomyoma and uterine leiomyoma. The relative excess risk of interaction (RERI),) was attributed to the proportion of interaction (AP) and the synergistic index (S) were used to evaluate the additive interaction between abortion history and family history of uterine leiomyoma. Results the multivariate conditional Logistic regression model showed that the history of abortion (OR1.39) and the family history of uterine leiomyoma (OR 2.0795 CI 1.363.15) were all risk factors of uterine leiomyoma. The history of abortion and the family history of uterine leiomyoma had an additive interaction on the risk of uterine leiomyoma (S5. 51A APN 0. 59 RERI 2. 14). The risk of uterine leiomyoma was increased by 1.78 times and 2.77 times respectively in the subjects with family history of uterine leiomyoma. Among the subjects with no genetic background, the incidence of uterine myoma was less affected by abortion experience. Conclusion the sensitive population with genetic background of uterine leiomyoma should pay attention to planning pregnancy and careful abortion in order to reduce the risk of uterine leiomyoma.
【作者单位】：山东大学公共卫生学院流行病与卫生统计学系;
【分类号】：R737.33

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