血管生成因子、抗血管生成因子表达变化在子痫前期发病中的作用机制研究进展
发布时间：2018-07-29 10:09
【摘要】：子痫前期的基本病理特征是母体全身血管内皮功能障碍。有证据表明,血管生成因子、抗血管生成因子表达改变可能与子痫前期的发病有关。母血中高水平的抗血管生成因子(如s Flt-1、s Eng、AT1、HIF-1α等)可破坏血管生成因子(如VEGF、PIGF等)的生物学功能,打破血管生成因子/抗血管生成因子生理性平衡状态,造成血管内皮细胞功能障碍,出现各组织细胞缺血缺氧,产生子痫前期临床症状。多项研究发现,母血s Flt-1/PIGF比值变化或可预测子痫前期的发生并评估病情,但该预测值还未纳入任何一项官方临床指南,仍需要后续研究证实。
[Abstract]:The basic pathological feature of preeclampsia is maternal systemic vascular endothelial dysfunction. There is evidence that the expression of angiogenic factors and anti-angiogenic factors may be associated with preeclampsia. The high level of anti-angiogenic factors (such as s Flt-1 / S Eng1 / HIF-1 伪) in maternal blood can destroy the biological function of angiogenic factors (such as VEGF PIGF, etc.) and break the physiologic balance of angiogenic factors / antiangiogenic factors. Causes vascular endothelial cell dysfunction, tissue cell ischemia and hypoxia, pre-eclampsia clinical symptoms. Several studies have found that changes in maternal blood s Flt-1/PIGF ratios may predict preeclampsia and assess the condition, but this prediction has not been included in any official clinical guidelines and needs to be confirmed in subsequent studies.
【作者单位】： 郑州大学第三附属医院;河南商丘医学高等专科学校;
【分类号】：R714.244
[Abstract]:The basic pathological feature of preeclampsia is maternal systemic vascular endothelial dysfunction. There is evidence that the expression of angiogenic factors and anti-angiogenic factors may be associated with preeclampsia. The high level of anti-angiogenic factors (such as s Flt-1 / S Eng1 / HIF-1 伪) in maternal blood can destroy the biological function of angiogenic factors (such as VEGF PIGF, etc.) and break the physiologic balance of angiogenic factors / antiangiogenic factors. Causes vascular endothelial cell dysfunction, tissue cell ischemia and hypoxia, pre-eclampsia clinical symptoms. Several studies have found that changes in maternal blood s Flt-1/PIGF ratios may predict preeclampsia and assess the condition, but this prediction has not been included in any official clinical guidelines and needs to be confirmed in subsequent studies.
【作者单位】： 郑州大学第三附属医院;河南商丘医学高等专科学校;
【分类号】：R714.244
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