体外受精—胚胎移植中非优质胚胎移植价值的评价
发布时间：2018-07-30 08:03
【摘要】：目的：通过新鲜移植周期与冷冻移植周期中非优质胚胎移植相关数据的分析,探讨非优质胚胎移植的价值。 方法：收集2012年1月—2013年1月在我院接受并完成第一周期长方案IVF-ET治疗的318个新鲜胚胎移植周期及2010年1月—2013年1月行冻融胚胎移植的667个周期不孕症患者的临床资料。以优质胚胎组为对照组,非优质胚胎为研究组,比较新鲜移植周期及冷冻移植周期在周期临床妊娠率、胚胎种植率、生化妊娠率、早期流产率、多胎率、宫外孕率及抱婴率等指标的差异。 结果：1.新鲜胚胎移植周期中,优质胚胎的临床妊娠率高于非优质胚胎组。非优质胚胎的临床妊娠率随着胚胎移植数目的增加而增加，移植3个胚胎时，其临床妊娠率接近优质胚胎组(分别为43.6%和44.0%)(p＞0.05)。2.冻融胚胎移植中,冷冻前后均为优质胚胎的临床妊娠率高于非优质胚胎组。未受损的非优质的临床妊娠率随胚胎移植数目的增加而增加。胚胎冻融后发生部分冷冻受损的胚胎临床妊娠率最低，增加冷冻损伤胚胎的移植数目并不能提高临床妊娠率。 结论：1.在新鲜胚胎移植周期中，当无优质胚胎时，移植非优质胚胎也有较好的成功率，，可以使用，不应放弃。2.非优质胚胎冻融复苏后，应选择卵裂球完好胚胎移植，放弃有破损的胚胎。
[Abstract]:Objective: to study the value of non-high quality embryo transfer by analyzing the data of fresh and frozen transfer cycles. Methods: the clinical data of 318 fresh embryo transfer cycles received and completed the first long term IVF-ET treatment in our hospital from January 2012 to January 2013 and 667 cycles of infertility patients undergoing frozen and thawed embryo transfer from January 2010 to January 2013 were collected. To compare the clinical pregnancy rate, embryo implantation rate, biochemistry pregnancy rate, early abortion rate, multiple pregnancy rate between fresh and frozen transfer cycles, the control group was used as the control group and the non-high quality embryo group as the study group. The difference of ectopic pregnancy rate and infantile rate. The result is 1: 1. The clinical pregnancy rate of high-quality embryos was higher than that of non-high-quality embryos in the fresh embryo transfer cycle. The clinical pregnancy rate of non-high quality embryos increased with the increase of the number of embryo transfer. When 3 embryos were transferred, the clinical pregnancy rate was close to that of the high quality embryo group (43.6% and 44.0%) (p > 0. 05). The clinical pregnancy rate of frozen and thawed embryos before and after freezing was higher than that of non-quality embryos. Undamaged non-quality clinical pregnancy rates increase with the number of embryo transplants. The clinical pregnancy rate of partially frozen damaged embryos after freeze-thawing was the lowest, and increasing the number of frozen damaged embryos could not improve the clinical pregnancy rate. Conclusion 1. In the fresh embryo transfer cycle, when there is no high-quality embryo, the transfer of non-high quality embryos also has a better success rate, can be used, should not give up. 2. After freeze-thaw resuscitation, cleavage ball should be selected for intact embryo transfer, and damaged embryo should be abandoned.
【学位授予单位】：遵义医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.8
本文编号：2154360
[Abstract]:Objective: to study the value of non-high quality embryo transfer by analyzing the data of fresh and frozen transfer cycles. Methods: the clinical data of 318 fresh embryo transfer cycles received and completed the first long term IVF-ET treatment in our hospital from January 2012 to January 2013 and 667 cycles of infertility patients undergoing frozen and thawed embryo transfer from January 2010 to January 2013 were collected. To compare the clinical pregnancy rate, embryo implantation rate, biochemistry pregnancy rate, early abortion rate, multiple pregnancy rate between fresh and frozen transfer cycles, the control group was used as the control group and the non-high quality embryo group as the study group. The difference of ectopic pregnancy rate and infantile rate. The result is 1: 1. The clinical pregnancy rate of high-quality embryos was higher than that of non-high-quality embryos in the fresh embryo transfer cycle. The clinical pregnancy rate of non-high quality embryos increased with the increase of the number of embryo transfer. When 3 embryos were transferred, the clinical pregnancy rate was close to that of the high quality embryo group (43.6% and 44.0%) (p > 0. 05). The clinical pregnancy rate of frozen and thawed embryos before and after freezing was higher than that of non-quality embryos. Undamaged non-quality clinical pregnancy rates increase with the number of embryo transplants. The clinical pregnancy rate of partially frozen damaged embryos after freeze-thawing was the lowest, and increasing the number of frozen damaged embryos could not improve the clinical pregnancy rate. Conclusion 1. In the fresh embryo transfer cycle, when there is no high-quality embryo, the transfer of non-high quality embryos also has a better success rate, can be used, should not give up. 2. After freeze-thaw resuscitation, cleavage ball should be selected for intact embryo transfer, and damaged embryo should be abandoned.
【学位授予单位】：遵义医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.8
【参考文献】
相关期刊论文 前5条
1 陈士岭;李劲;孙玲;邢福祺;;取卵后第3天胚胎形态学指标与移植后着床的关系[J];实用妇产科杂志;2007年02期
2 王贺;李蓉;郝桂琴;;体外受精-胚胎移植周期中第3天移植胚胎细胞数与妊娠率的相关性[J];生殖医学杂志;2007年04期
3 何驰华;皮洁;朱敬香;;睾丸取精卵胞浆内单精子注射术后第3天移植四细胞胚胎获妊娠一例[J];生殖医学杂志;2008年06期
4 刘风华;何玲;;辅助生殖技术出生儿近期安全性评价[J];现代妇产科进展;2010年03期
5 戴善军;孙莹璞;苏迎春;郭艺红;辛志敏;金海霞;;体外受精非优质胚胎冻融的临床价值[J];徐州医学院学报;2007年04期
本文编号：2154360
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2154360.html
最近更新
教材专著
