孕期血糖逆向增高与妊娠结局的关系研究

发布时间：2018-07-31 15:35

【摘要】：目的探讨孕期75g葡萄糖耐量试验(OGTT)结果逆向增高与妊娠结局的关系。方法采用回顾性分析的研究方法,收集2014年南方医科大学珠江医院常规产检及分娩的孕产妇资料,选取服糖后2h血糖高于1h血糖者226例为观察组,随机抽取同期分娩的无妊娠期糖尿病(GDM)及糖尿病者235例为对照组。结果观察组OGTT结果空腹血糖、服糖后1h血糖均低于对照组,而服糖后2h血糖高于对照组,差异均有统计学意义(P0.01)。观察组羊水过多、羊水过少、胎儿生长受限(FGR)、早产、妊娠合并高血压疾病、胎膜早破、胎死宫内、非疤痕子宫剖宫产的发生率以及新生儿发育异常率、窒息率均高于对照组,但差异无统计学意义(P0.05)。对照组新生儿转科率低于观察组,差异有统计学意义(P0.01)。结论孕期OGTT结果逆向增高者存在血糖代谢延迟,可能影响新生儿的远期预后,临床上应加强对该部分孕妇的孕期管理。
[Abstract]:Objective to investigate the relationship between the adverse increase of (OGTT) results in 75 g glucose tolerance test during pregnancy and pregnancy outcome. Methods A retrospective study was conducted to collect the data of pregnant and parturient in the Pearl River Hospital of Southern Medical University in 2014. 226 patients with 2 h blood glucose and 1 h blood glucose were selected as the observation group. A total of 235 cases of gestational diabetes mellitus (GDM) and diabetes mellitus (DM) were randomly selected as control group. Results the fasting blood glucose and blood glucose at 1 hour after taking glucose in the observation group were lower than those in the control group, while the blood glucose at 2 hours after taking glucose was higher than that in the control group (P0.01). In the observation group, the incidence of amniotic fluid excess, oligohydramnios, (FGR), premature delivery, pregnancy complicated with hypertension, premature rupture of membranes, intrauterine fetal death, cesarean section of non-scar uterus, abnormal development rate of newborn and asphyxia rate were higher than those in the control group. But the difference was not statistically significant (P0.05). The rate of neonatal transfer in the control group was lower than that in the observation group (P 0.01). Conclusion the delayed metabolism of blood glucose may affect the long-term prognosis of newborns in patients with adverse increase of OGTT during pregnancy, so the pregnant management should be strengthened clinically.
【作者单位】：南方医科大学珠江医院妇产科;
【分类号】：R714.256

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