补充黄体酮对低孕酮水平早期妊娠结局的影响

发布时间：2018-08-03 07:39

【摘要】：目的探讨补充黄体酮对低孕酮水平早期妊娠结局的影响。方法选择2014年1月1日~2014年8月31日在西电集团医院妇产科门诊就诊的临床确诊为宫内妊娠、单胎、孕5~10w、自然受孕、血清孕酮水平为5~25ng/ml的早期妊娠妇女作为研究对象,有以下之一者排除研究:有先兆流产症状、辅助生殖、可疑异位妊娠、不良早期妊娠史、要求终止妊娠、就诊前使用孕酮制剂、子宫肌瘤、子宫畸形、合并内外科疾病。将符合以上研究标准的早期妊娠妇女305例作为研究对象,随访其孕期黄体酮补充情况及孕满12周妊娠结局,其中完成随访296例,失访9例,将完成随访的296例孕妇按照其黄体酮补充情况进行分组,接受黄体酮补充治疗的早期妊娠妇女226例作为研究组,未接受黄体酮补充治疗的早期妊娠妇女70例作为对照组,两组孕妇均随访至孕满12w,比较两组早期妊娠结局。结果研究组妊娠存活率为81.42%,妊娠丢失率为18.58%;对照组妊娠存活率为74.29%,妊娠丢失率为25.71%,两组比较无显著性差异(P=0.195)。结论对于低孕酮水平早期妊娠的健康妇女,无先兆流产症状以及无不良早期妊娠史者进行黄体酮补充治疗未能明显改善早期妊娠结局。
[Abstract]:Objective to explore the effect of progesterone supplementation on the early pregnancy outcome at the level of low progesterone. Methods the clinical diagnosis of intrauterine pregnancy, single fetus, pregnancy 5~10w, natural pregnancy, and serum progesterone level of 5~25ng/ ml in early pregnancy women in the clinic of Obstetrics and gynecology in Xidian group hospital, January 1, 2014 ~2014 years were selected as the research object. One of the subjects excluded: symptoms of threatened abortion, assisted reproduction, suspected ectopic pregnancy, bad early pregnancy history, requiring termination of pregnancy, using progesterone preparation, uterine myoma, uterine malformation, and internal and external diseases before the treatment. 305 early pregnant women who were in conformity with the above criteria were followed up with progesterone supplementation during pregnancy. Among the 12 weeks of pregnancy, 296 cases were followed up and 9 cases were lost. 296 pregnant women were followed up with progesterone supplementation, 226 early pregnant women received progesterone supplementation as the study group, and 70 of the early pregnancy women who did not receive progesterone supplementation as the control group. The two group of pregnant women were all followed. The outcome of the two groups was compared with the two groups of early pregnancy outcomes. The results showed that the pregnancy survival rate was 81.42%, the pregnancy loss rate was 18.58%, the pregnancy survival rate of the control group was 74.29%, the pregnancy loss rate was 25.71%, the two groups had no significant difference (P=0.195). Conclusion there was no threatened abortion symptoms and no symptoms for the healthy women with low progesterone level in the early pregnancy. Progesterone supplementation did not significantly improve early pregnancy outcomes in patients with good early pregnancy.
【作者单位】：陕西中医药大学;中国西电集团医院妇产科;
【分类号】：R714.21

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