达英-35和二甲双胍对多囊卵巢综合征不孕患者性激素水平及胰岛素抵抗的影响

发布时间：2018-08-04 12:33

【摘要】：目的探讨达英-35和二甲双胍对多囊卵巢综合征不孕患者性激素水平及胰岛素抵抗的影响。方法选择2013年1月~2015年1月山东省淄博市莲池妇婴医院收治的80例多囊卵巢综合征不孕患者,采用随机数字表法分为观察组和对照组,每组各40例。对照组予达英-35治疗,观察组予达英-35联合二甲双胍治疗,共治疗3个疗程。比较两组临床疗效、治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、雌二醇(E2)水平及胰岛素抵抗指数(HOMA-IR)的变化。结果治疗后,观察组总有效率为95.0%,对照组总有效率为75.0%,差异有统计学意义(P0.05)。治疗前,两组LH、FSH、E2、T水平及HOMA-IR比较,差异无统计学意义(P0.05)。治疗后,观察组LH、FSH、T水平及HOMA-IR均较治疗前及对照组显著降低(P0.05),E2水平较治疗前及对照组显著升高(P0.05或P0.01)。结论达英-35和二甲双胍联合治疗多囊卵巢综合征不孕患者具有协同作用,可以显著改善性激素水平及胰岛素抵抗,是一种较理想的治疗方法,值得推广应用。
[Abstract]:Objective to investigate the effects of diane-35 and metformin on the levels of sex hormones and insulin resistance in infertile women with polycystic ovary syndrome (PCOS). Methods from January 2013 to January 2015, 80 patients with polycystic ovary syndrome (PCOS) admitted in Lianchi Gynecological and Infant Hospital of Zibo City, Shandong Province were randomly divided into observation group and control group with 40 cases in each group. The control group was treated with daying-35 and the observation group with metformin for 3 courses. The changes of serum follicle stimulating hormone (FSH),) luteinizing hormone (LH),) testosterone (T), estradiol (E 2) and insulin resistance index (HOMA-IR) before and after treatment were compared between the two groups. Results after treatment, the total effective rate of observation group was 95.0 and that of control group was 75.0, the difference was statistically significant (P0.05). Before treatment, there was no significant difference between the two groups (P0.05) in the level of E2T and HOMA-IR. After treatment, the levels of HOMA-IR and HOMA-IR in observation group were significantly lower than those before treatment and control group (P0.05) and E2 level was significantly higher than that before treatment and control group (P0.05 or P0.01). Conclusion the combination of Daf-35 and metformin in the treatment of infertility with polycystic ovary syndrome has synergistic effect and can significantly improve the level of sex hormone and insulin resistance. It is an ideal treatment method and is worth popularizing.
【作者单位】：山东省淄博市莲池妇婴医院妇产科;
【分类号】：R711.75

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