子宫内膜样腺癌合并盆腔淋巴结淋巴管肌瘤病的临床病理分析
发布时间：2018-08-05 18:52
【摘要】：目的 探讨淋巴结淋巴管肌瘤病(lymphangiomyomatosis,LAM)的临床病理学特征。方法 复习1例子宫内膜样腺癌合并盆腔淋巴结LAM的临床资料及病理特征,对其行HE及免疫组化En Vision法染色并复习相关文献。结果 子宫内膜呈高-中分化子宫内膜样腺癌改变,盆腔淋巴结被膜及髓质内见增生的LAM细胞呈梭形、上皮样或多角形,围绕腔隙排列,细胞质嗜酸性或空泡样,细胞无明显异型性,未见核分裂象。免疫表型:SMA、Caldesmon、desmin、vimentin、ER和PR均阳性,腔隙内衬细胞CD34和D2-40均阳性,上皮样瘤细胞HMB-45阳性,Melan-A阴性,Ki-67增殖指数1%。结论 LAM临床较为少见,好发于肺部,子宫内膜样腺癌合并盆腔淋巴结LAM极为罕见,结合组织学形态、临床特点及免疫组化染色可确诊,为今后进一步分析LAM的机制及治疗提供重要价值。
[Abstract]:Objective to investigate the clinicopathological features of lymphangiomyomyosis laminae (Lam) in lymph nodes. Methods the clinical and pathological features of a case of endometrioid adenocarcinoma with pelvic lymph node LAM were reviewed, and the relevant literatures were reviewed by HE and immunohistochemical staining with en Vision method. Results the endometrium showed a well-differentiated endometrial adenocarcinoma. The proliferative LAM cells were spindle-shaped, epithelioid or polygonal, arranged around the lacunae, cytoplasm eosinophilic or vacuolar, in pelvic lymph node capsule and medulla. There was no obvious heterogeneity and no mitotic appearance in the cells. The immunophenotype was positive for ER and PR, positive for CD34 and D2-40 in lacunar lining cells, and positive for HMB-45 positive for epithelioid tumor cells. The Ki-67 proliferative index was 1% in epithelioid tumor cells. Conclusion LAM is rare in clinic, it is prone to occur in lung, and LAM in pelvic lymph nodes is extremely rare in endometrioid adenocarcinoma. Combined with histological morphology, clinical features and immunohistochemical staining, it can be diagnosed. It provides important value for further analysis of the mechanism and treatment of LAM.
【作者单位】： 山东省聊城市第二人民医院病理科;山东省聊城市第二人民医院妇科;
【分类号】：R737.33
[Abstract]:Objective to investigate the clinicopathological features of lymphangiomyomyosis laminae (Lam) in lymph nodes. Methods the clinical and pathological features of a case of endometrioid adenocarcinoma with pelvic lymph node LAM were reviewed, and the relevant literatures were reviewed by HE and immunohistochemical staining with en Vision method. Results the endometrium showed a well-differentiated endometrial adenocarcinoma. The proliferative LAM cells were spindle-shaped, epithelioid or polygonal, arranged around the lacunae, cytoplasm eosinophilic or vacuolar, in pelvic lymph node capsule and medulla. There was no obvious heterogeneity and no mitotic appearance in the cells. The immunophenotype was positive for ER and PR, positive for CD34 and D2-40 in lacunar lining cells, and positive for HMB-45 positive for epithelioid tumor cells. The Ki-67 proliferative index was 1% in epithelioid tumor cells. Conclusion LAM is rare in clinic, it is prone to occur in lung, and LAM in pelvic lymph nodes is extremely rare in endometrioid adenocarcinoma. Combined with histological morphology, clinical features and immunohistochemical staining, it can be diagnosed. It provides important value for further analysis of the mechanism and treatment of LAM.
【作者单位】： 山东省聊城市第二人民医院病理科;山东省聊城市第二人民医院妇科;
【分类号】：R737.33
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