氯喹那多-普罗雌烯与硝酸咪康唑治疗单纯性外阴阴道假丝酵母菌病的疗效与安全性比较

发布时间：2018-08-06 18:17

【摘要】：目的:比较氯喹那多-普罗雌烯与硝酸咪康唑治疗单纯性外阴阴道假丝酵母菌病(VCC)的疗效与安全性。方法:回顾性分析231例单纯性VCC患者资料,按用药方案的不同分为观察组(116例)和对照组(115例)。观察组患者给予氯喹那多-普罗雌烯阴道片0.2 g,每晚1次,阴道上药。对照组患者给予硝酸咪康唑栓200 mg,每晚1次,阴道上药。两组均以7 d为1个疗程。观察两组患者第1次及第2次复查时的临床疗效,第2次复查时两组总有效患者的症状缓解时间及复发情况,并记录两组患者不良反应发生情况。结果:第1次、第2次复查时两组患者总有效率及第2次复查时两组总有效患者症状缓解时间比较,差异均无统计学意义(P0.05)。第2次复查时,观察组总有效患者复发率显著低于对照组,差异有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:氯喹那多-普罗雌烯与硝酸咪康唑治疗单纯性VCC疗效和安全性均相当,但氯喹那多-普罗雌烯在降低复发率方面优于硝酸咪康唑。
[Abstract]:Objective: to compare the efficacy and safety of chloroquinado-praestriene and miconazole nitrate in the treatment of simple vulvovaginal candidiasis (VCC). Methods: the data of 231 patients with simple VCC were retrospectively analyzed and divided into observation group (116 cases) and control group (115 cases). The patients in the observation group were given 2. 2 g chloroquinado-proestrin vaginal tablets once a night. Patients in the control group were given miconazole nitrate suppository 200 mg, once a night, vaginal administration. Both groups were treated with 7 days as a course of treatment. To observe the clinical effect of the first and second reexamination of the two groups, the time of symptom remission and recurrence of the total effective patients in the two groups at the second time, and to record the occurrence of adverse reactions in the two groups. Results: there was no significant difference in the total effective rate between the two groups at the first and second time and the remission time between the two groups at the second time (P0.05). At the second reexamination, the total effective recurrence rate in the observation group was significantly lower than that in the control group, the difference was statistically significant (P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion: the efficacy and safety of chloroquinado-praestriene and miconazole nitrate in the treatment of simple VCC are similar, but chloroquinado-proestriol is superior to miconazole nitrate in reducing the recurrence rate.
【作者单位】：重庆医科大学附属第一医院;重庆医科大学附属第二医院;
【分类号】：R711.31

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