妊娠期肝内胆汁淤积症血清总胆汁酸与新生儿肺损伤程度的相关性

发布时间：2018-08-06 19:14

【摘要】：目的探讨妊娠肝内胆汁淤积综合征(ICP)孕妇血清总胆汁酸(TBA)与新生儿肺损伤程度的相关性。方法收集2014年3月至2015年12月于沙坪坝区人民医院产科住院剖宫产分娩的52例ICP孕妇及其新生儿(ICP组),配对选取52例剖宫产孕妇及其新生儿作为对照组,记录各组新生儿发生肺损伤的情况,分析孕妇TBA水平及高血清TBA暴露时间与新生儿肺损伤的相关性。结果 ICP组新生儿肺损伤发生率(67.3%)明显高于对照组(17.3%),差异有统计学意义(P0.05);孕妇血清TBA水平与新生儿肺损伤程度呈正相关(r=0.687,P=0.000),高血清TBA暴露时间与肺损伤程度呈正相关(r=0.523,P=0.001)。结论 ICP孕妇所生产的新生儿发生肺损伤的概率明显升高,并且肺损伤程度与孕妇TBA水平及胎儿高血清TBA暴露时间呈正相关。
[Abstract]:Objective to investigate the relationship between serum total bile acid (TBA) and neonatal lung injury in pregnant women with intrahepatic cholestasis of pregnancy (ICP). Methods from March 2014 to December 2015, 52 ICP pregnant women and their newborns (ICP group) who were hospitalized by cesarean section in the people's Hospital of Shapingba District were selected as the control group. The incidence of lung injury in neonates in each group was recorded and the correlation between neonatal lung injury and TBA level and exposure time of high serum TBA was analyzed. Results the incidence of neonatal lung injury in the ICP group (67.3%) was significantly higher than that in the control group (17.3%), the difference was statistically significant (P0.05), the serum TBA level of pregnant women was positively correlated with the degree of neonatal lung injury (r = 0.687P0. 000), and the exposure time of high serum TBA was positively correlated with the degree of lung injury (r = 0. 523, P 0. 001). Conclusion the probability of lung injury in the newborn born to pregnant women with ICP was significantly increased, and the degree of lung injury was positively correlated with the TBA level of pregnant women and the exposure time of fetal high serum TBA.
【作者单位】：重庆市沙坪坝区人民医院儿科;第三军医大学大坪医院野战外科研究所儿科;
【基金】：重庆市卫生局医学科研项目(2013-2-200)
【分类号】：R714.7

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