孕妇妊娠期甲状腺激素水平变化及与TPOAb的相关性研究

发布时间：2018-08-08 13:24

【摘要】：目的探讨孕妇妊娠期甲状腺激素水平变化及与抗甲状腺过氧化物酶抗体(TPOAb)的相关性。方法选取2012年11月至2014年5月来宁夏回族自治区石嘴山市妇幼保健院进行检查的150例孕妇作为研究对象,根据TPOAb对孕妇进行分组。比较两组孕妇的临床资料、血清甲状腺激素水平、妊娠结局和新生儿并发症的发生率。结果 150例患者中,TPOAb阳性者44例,阴性106例。两组孕妇的年龄、孕周和BMI差异无统计学意义(P0.05)。妊娠早中期和晚期,两组孕妇的甲状腺激素水平差异有统计学意义(P0.05);观察组(TPOAb阳性)孕妇妊娠前后的甲状腺激素水平差异有统计学意义(P0.05)。两组孕妇的不良妊娠结局和新生儿并发症的发生率差异有统计学意义(P0.05)。结论妊娠期的TPOAb对妊娠期亚临床甲状腺功能减退的诊断和妊娠结局的判断具有一定的意义。
[Abstract]:Objective to investigate the changes of thyroid hormone in pregnant women and its correlation with anti-thyroid peroxidase antibody (TPOAb). Methods from November 2012 to May 2014, 150 pregnant women from Shizuishan Maternal and Child Health Hospital of Ningxia Hui Autonomous region were selected as the study objects. The pregnant women were grouped according to TPOAb. The clinical data, serum thyroid hormone level, pregnancy outcome and incidence of neonatal complications were compared between the two groups. Results among 150 patients, 44 were positive for TPOAb and 106 were negative. There was no significant difference in age, gestational age and BMI between the two groups (P0.05). The difference of thyroid hormone level between the two groups was statistically significant (P0.05), while that of the observation group (TPOAb positive) was statistically significant before and after pregnancy (P0.05). There was significant difference in the incidence of adverse pregnancy outcomes and neonatal complications between the two groups (P0.05). Conclusion TPOAb during pregnancy has a certain significance in the diagnosis of subclinical hypothyroidism and the outcome of pregnancy.
【作者单位】：宁夏回族自治区石嘴山市妇幼保健院妇产科;宁夏医科大学总医院妇产科;
【基金】：国家自然科学基金资助项目(30960114)
【分类号】：R714.256

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