四种血清脂蛋白比值对多囊卵巢综合征患者发生代谢综合征的诊断预测价值
发布时间：2018-08-10 19:59
【摘要】：目的研究并比较低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C/high density lipoprotein-cholesterol,HDL-C)、载脂蛋白B/载脂蛋白AI(apolipoprotein B,Apo B/Apo AI)、三酰甘油/高密度脂蛋白胆固醇(triglyceride,TG/HDL-C)、总胆固醇/高密度脂蛋白胆固醇(total cholesterol,TC/HDL-C)4种血清脂蛋白比值对多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者发生代谢综合征(metabolic syndrome,MS)的诊断预测价值。方法选取2014年1月至2015年5月在首都医科大学附属北京妇产医院内分泌科就诊的PCOS患者441例,年龄15~44岁,空腹抽血查性激素、血糖、血脂、胰岛素等,按2005年国际糖尿病联盟的MS诊断标准比较MS组与非MS组在年龄、血压、体质量指数(body mass index,BMI)、腰围、腰臀比等指标的差异。分析LDL-C/HDL-C、Apo B/Apo AI、TG/HDL-C、TC/HDL-C比值与MS各组分的相关性。再根据MS诊断标准中的5个组分将441例患者分为0~5项异常组,分析各组4个比值的均值差异有无统计学意义。ROC曲线确定4者诊断MS的临界值(cutoff),并比较4者对PCOS患者发生MS的诊断预测效果。结果 LDL-C/HDL-C、Apo B/Apo AI、TG/HDL-C、TC/HDL-C均值总体上随代谢综合征异常指标项数的增加而升高,且与代谢综合征各组分均明显相关。4个比值中以TG/HDL-C的ROC曲线下面积最大为0.941。其cutoff值定为1.089时,诊断代谢综合征的灵敏度为0.864,特异度0.891,此时诊断代谢综合征的价值最大。结论 LDL-C/HDL-C、Apo B/Apo AI、TG/HDL-C、TC/HDL-C均值均随代谢综合征异常组分项数的增多而增加,且与MS各诊断指标相关,以TG/HDL-C对MS的诊断预测价值最大。临床上当TG/HDL-C≥1.089时,应警惕患者已经发生或即将发生MS,及时进行药物和生活方式的干预,避免或延缓MS的发生。
[Abstract]:Objective to study and compare LDL-C / high density protein-cholesterol HDL-C (LDL-C / high density protein-cholesterol), apolipoprotein B / apolipoprotein AI (apolipoprotein B/Apo AI), triacylglycerol / high density lipoprotein cholesterol (TG / HDL-C), total cholesterol / high density lipoprotein cholesterol (HDL-C). Prognostic value of four serum lipoprotein ratios of total cholesterol TC / HDL-C in the diagnosis of metabolic syndrome (metabolic syndrome) in patients with polycystic ovary syndrome (polycystic ovary / HDL-C). Methods from January 2014 to May 2015, 441 PCOS patients, aged 1544 years, were selected from the Endocrinology Department of Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University. Fasting blood samples were taken for sex hormones, blood glucose, blood lipids, insulin and so on. The differences of age, blood pressure, body mass index (body mass), waist circumference and waist-to-hip ratio between MS group and non-MS group were compared according to the MS diagnostic criteria of the International Diabetes Federation in 2005. The correlation between the ratio of TG / HDL-C / TC / HDL-C and the components of MS was analyzed. According to the five components of MS diagnostic criteria, 441 patients were divided into 0 or 5 abnormal groups. To analyze the difference of the mean value of the four ratios in each group. The ROC curve was used to determine the critical value of (cutoff), for the diagnosis of MS in 4 patients and to compare the diagnostic and predictive effects of the 4 groups on the occurrence of MS in the patients with PCOS. Results the mean value of TG / HDL-C + TC- / HDL-C increased with the increase of abnormal items of metabolic syndrome, and was significantly related to the components of metabolic syndrome. The area under the ROC curve of TG/HDL-C was 0.941 in all the four ratios. When the cutoff value was 1.089, the sensitivity and specificity of metabolic syndrome were 0.864 and 0.891respectively. Conclusion the mean value of TG / HDL-C + TC-1 / HDL-C + T / HDL-C / C ratio increased with the increase of the number of sub-items in abnormal metabolic syndrome group, and was related to the diagnosis indexes of MS. The diagnostic value of TG/HDL-C was the most important in the diagnosis of MS. When TG/HDL-C 鈮，
本文编号：2176042
[Abstract]:Objective to study and compare LDL-C / high density protein-cholesterol HDL-C (LDL-C / high density protein-cholesterol), apolipoprotein B / apolipoprotein AI (apolipoprotein B/Apo AI), triacylglycerol / high density lipoprotein cholesterol (TG / HDL-C), total cholesterol / high density lipoprotein cholesterol (HDL-C). Prognostic value of four serum lipoprotein ratios of total cholesterol TC / HDL-C in the diagnosis of metabolic syndrome (metabolic syndrome) in patients with polycystic ovary syndrome (polycystic ovary / HDL-C). Methods from January 2014 to May 2015, 441 PCOS patients, aged 1544 years, were selected from the Endocrinology Department of Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University. Fasting blood samples were taken for sex hormones, blood glucose, blood lipids, insulin and so on. The differences of age, blood pressure, body mass index (body mass), waist circumference and waist-to-hip ratio between MS group and non-MS group were compared according to the MS diagnostic criteria of the International Diabetes Federation in 2005. The correlation between the ratio of TG / HDL-C / TC / HDL-C and the components of MS was analyzed. According to the five components of MS diagnostic criteria, 441 patients were divided into 0 or 5 abnormal groups. To analyze the difference of the mean value of the four ratios in each group. The ROC curve was used to determine the critical value of (cutoff), for the diagnosis of MS in 4 patients and to compare the diagnostic and predictive effects of the 4 groups on the occurrence of MS in the patients with PCOS. Results the mean value of TG / HDL-C + TC- / HDL-C increased with the increase of abnormal items of metabolic syndrome, and was significantly related to the components of metabolic syndrome. The area under the ROC curve of TG/HDL-C was 0.941 in all the four ratios. When the cutoff value was 1.089, the sensitivity and specificity of metabolic syndrome were 0.864 and 0.891respectively. Conclusion the mean value of TG / HDL-C + TC-1 / HDL-C + T / HDL-C / C ratio increased with the increase of the number of sub-items in abnormal metabolic syndrome group, and was related to the diagnosis indexes of MS. The diagnostic value of TG/HDL-C was the most important in the diagnosis of MS. When TG/HDL-C 鈮，
本文编号：2176042
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