赖氨酰氧化酶在子宫内膜癌中的表达及意义

发布时间：2018-08-10 20:24

【摘要】：目的探讨赖氨酰氧化酶(LOX)在子宫内膜癌组织、子宫内膜良性增生组织中的表达规律及其与子宫内膜癌预后指标的相关性。方法应用免疫组化法检测53例子宫内膜癌、90例子宫内膜单纯性增生及复杂性增生组织中LOX蛋白的表达,比较LOX蛋白在良、恶性子宫内膜病变组织中表达的差异,分析LOX蛋白的表达与子宫内膜癌的临床分期、是否存在淋巴结转移及细胞分化程度等预后指标的相关性。结果 LOX蛋白在子宫内膜癌组织中的阳性表达率为52.8%,在子宫内膜复杂性增生组织中的表达率为32.5%,子宫内膜单纯性增生组织中的表达率为24.0%。子宫内膜癌、子宫内复杂性增生及子宫内膜单纯性增生组织中LOX蛋白表达率差异有统计学意义(P=0.008)。子宫内膜癌组织中LOX蛋白的表达与临床分期、细胞分化及淋巴结转移有相关性。Ⅰ~Ⅳ期子宫内膜癌阳性表达率分别为31.6%、50.0%、78.6%和75.0%,组间差异有统计学意义(P=0.006)。在高、中、低分化组的阳性表达率分别为32.0%、60.0%、84.6%,组间差异有统计学意义(P=0.007);有淋巴结转移及无淋巴结转移组的阳性率为78.6%及43.7%,差异有统计学意义(P=0.025)。结论子宫内膜癌组织中LOX表达明显高于子宫内膜复杂性增生及子宫内膜单纯性增生,LOX参与子宫内膜癌的侵袭及转移的病理过程。
[Abstract]:Objective to investigate the expression of lysyl oxidase (LOX) in endometrial carcinoma and endometrial benign hyperplasia and its correlation with the prognosis of endometrial carcinoma. Methods Immunohistochemical method was used to detect the expression of LOX protein in 53 cases of endometrial carcinoma and 90 cases of endometrial simple hyperplasia and complex hyperplasia, and to compare the expression of LOX protein in benign and malignant endometrial lesions. To analyze the correlation between the expression of LOX protein and the clinical stage, lymph node metastasis and cell differentiation of endometrial carcinoma. Results the positive expression rate of LOX protein was 52.8% in endometrial carcinoma, 32.5% in complex endometrial hyperplasia and 24.0% in endometrial simple hyperplasia. The expression rate of LOX protein in endometrial carcinoma, complex hyperplasia and simple hyperplasia of endometrium was significantly different (P0. 008). The expression of LOX protein in endometrial carcinoma was correlated with clinical stage, cell differentiation and lymph node metastasis. The positive expression rates of LOX protein in endometrial carcinoma in stage 鈪，

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