宫腔粘连和子宫纵隔的宫腔镜手术预后与TGF-β1的关系

发布时间：2018-08-11 16:46

【摘要】：目的:探讨转化生长因子-β1(transforming growth factor-β1,TGF-β1)在宫腔粘连和子宫纵隔患者宫腔镜术后子宫内膜中的不同表达与预后之间的关系。方法:选取2014年6月至2015年5月在西安交通大学第二附属医院行宫腔镜手术的患者96例,其中宫腔粘连、子宫纵隔患者各48例,用免疫组化SP法检测TGF-β1在患者术后3周子宫内膜中的表达情况,术后3个月按NASR评分将宫腔粘连和子宫纵隔患者分为预后良好组、预后一般组和预后不良组,用方差分析及卡方检验分析各组数据之间的差异。结果:宫腔镜术后3个月,子宫纵隔手术预后优于宫腔粘连,差异有统计学意义(χ~2=13.714,P=0.000);免疫组化染色结果显示,在宫腔粘连患者中,TGF-β1在预后不良组中的表达水平(n=16,2.94±0.70)明显高于预后一般组(n=20,1.65±0.76)和预后良好组(n=12,1.08±0.79),差异有统计学意义(P=0.000,P=0.000),在预后一般组中的表达高于预后良好组,差异有统计学意义(P=0.045);在子宫纵隔患者中,TGF-β1在预后不良组中的表达水平(n=6,2.58±0.97)明显高于预后一般组(n=12,1.25±0.54)和预后良好组(n=30,0.78±0.55),差异有统计学意义(P=0.000,P=0.000),在预后一般组中的表达高于预后良好组,差异有统计学意义(P=0.030)。结论:宫腔粘连和子宫纵隔宫腔镜手术预后差异可能与TGF-β1在子宫内膜中的异常表达有关,其预后不良可能与TGF-β1在子宫内膜中的过度表达有关。
[Abstract]:Objective: to investigate the relationship between the expression of transforming growth factor 尾 1 (transforming growth factor- 尾 1 (TGF- 尾 1) in endometrium and prognosis after hysteroscopy in patients with intrauterine adhesion and mediastinum. Methods: from June 2014 to May 2015, 96 patients underwent hysteroscopic surgery in the second affiliated Hospital of Xi'an Jiaotong University, including 48 cases of uterine cavity adhesion and 48 cases of uterine mediastinum. Immunohistochemical SP method was used to detect the expression of TGF- 尾 1 in endometrium 3 weeks after operation. According to NASR score, the patients with intrauterine adhesion and mediastinum were divided into three groups: good prognosis group, general prognosis group and poor prognosis group. Variance analysis and chi-square test were used to analyze the differences between groups. Results: three months after hysteroscopy, the prognosis of uterine mediastinal surgery was better than that of intrauterine adhesion (蠂 ~ (2 +) 13.714 ~ (0.000). The expression of TGF- 尾 1 in patients with intrauterine adhesion was significantly higher than that in patients with normal prognosis (n = 201.65 卤0.76) and good prognosis (n = 120.08 卤0.79). The expression of TGF- 尾 1 in poor prognosis group was higher than that in good prognosis group (P = 0.000, P 0.000), and the expression of TGF- 尾 1 in normal group was higher than that in good prognosis group (P < 0.05), and the expression of TGF- 尾 1 in patients with intrauterine adhesion was significantly higher than that in normal group with good prognosis (P < 0.05). The expression of TGF- 尾 1 in the patients with mediastinal uterine septum was significantly higher than that in the normal group (121.25 卤0.54) and the group with good prognosis (0.78 卤0.55), and the expression of TGF- 尾 1 in the group with poor prognosis was higher than that in the group with good prognosis (P 0.000 P 0.000), and the expression of TGF- 尾 1 in the normal group was higher than that in the group with good prognosis. The difference was statistically significant (P0. 030). Conclusion: the difference of prognosis between intrauterine adhesion and hysteroscopic surgery may be related to the abnormal expression of TGF- 尾 1 in endometrium, and the poor prognosis may be related to the overexpression of TGF- 尾 1 in endometrium.
【作者单位】：西安交通大学第二附属医院妇产科;
【基金】：社会发展科技攻关资助项目(编号:2016SF-030)
【分类号】：R713.4

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