加味平积汤对子宫肌瘤患者雌激素受体基因α单核苷酸多态性不同分型影响的临床研究
发布时间：2018-08-12 15:54
【摘要】：目的：观察子宫肌瘤患者外周血ERα基因rs9340799位点的分型(AA/AG型)。评估加味平积汤对子宫肌瘤患者外周血ER α基因rs9340799位点的分型(AA/AG型)的临床疗效。探讨子宫肌瘤的发生发展与ER α基因rs9340799位点的分型(AA/AG型)相关性。探索加味平积汤治疗子宫肌瘤的特色和优势,为子宫肌瘤的中医药防治方法和药物的研究提供一些参考,评估加味平积汤对ER α基因特定位点不同基因分型的有效率,从而更好的指导临床的治疗。 方法：选择符合纳入标准的子宫肌瘤患者60例,用加味平积汤分别治疗纯合(AA)组30例、杂合(AG)组30例,在非经期服药,疗程为3个月,于疗程结束后,统计分析治疗前后中医证候评分及子宫肌瘤体积的变化。 结果：1.中医证候积分改善情况：AA组与AG组肌瘤患者的临床症状都得以改善(P0.05),治疗后两组中医证候积分均有降低,且AA组优于AG组,差异有统计学意义(P0.05)。2.子宫体积及肌瘤大小、积分改善情况：两组治疗后子宫体积、肌瘤面积、肌瘤积分差异无统计学意义(P0.05)。两组的子宫体积及肌瘤面积治疗前后比较差异均有统计学意义(P0.05)。AA组肌瘤积分治疗前后差异有统计学意义(P0.05),AG组肌瘤积分治疗前后差异无统计学意义(P0.05)。结合均值可知,加味平积汤对AA组缩小子宫体积、缩瘤及降低肌瘤积分效果要优于AG组。3..疗效比较：AA组与AG组中医证候疗效分别是73.3%与33.3%；两组治疗后肌瘤疗效分别是33.3%和10%;综合疗效分别是80%与40%。可知,AA组可明显改善临床症状,对缩小肌瘤面积有一定的作用,效果较AG组显著；AA组综合疗效明显优于AG组。 结论：加味平积汤可明显改善临床症状,同时中药的扶正化瘀、清利散结的作用,祛邪而不伤正,在一定程度上抑制和延缓了肌瘤的发展,这一点是经过临床验证的。通过基因筛查,在基因药物未成熟之前,通过中医药则能更好的对子宫肌瘤患者进行个体化治疗,减轻患者的经济负担,着实很有意义。
[Abstract]:Objective: to observe the typing of ER 伪 gene rs9340799 locus (AA/AG type) in peripheral blood of patients with uterine leiomyoma. To evaluate the clinical effect of Jiawei Pingji decoction on the classification of ER 伪 gene rs9340799 locus (AA/AG type) in peripheral blood of patients with uterine leiomyoma. To investigate the relationship between the occurrence and development of uterine leiomyoma and the type of ER 伪 gene rs9340799 (AA/AG type). To explore the characteristics and advantages of Jiawei Pingji decoction in the treatment of uterine leiomyoma, to provide some references for the prevention and treatment of uterine leiomyoma with traditional Chinese medicine, and to evaluate the effective rate of Jiawei Pingji decoction for different genotyping of ER 伪 gene. So as to better guide the clinical treatment. Methods: sixty patients with uterine leiomyoma who met the inclusive criteria were treated with Jiawei Pingji decoction for 30 cases in pure (AA) group and 30 cases in heterozygous (AG) group. The course of treatment was 3 months after the end of the course of treatment. The changes of TCM syndrome score and uterine myoma volume before and after treatment were statistically analyzed. The result is 1: 1. The improvement of TCM syndromes score was improved in group A and AG (P0.05). After treatment, the score of TCM syndromes in group AA was lower than that in group AG, and the difference was statistically significant (P0.05). Uterine volume and myoma size, integral improvement: there was no significant difference in uterine volume, myoma area and myoma score between the two groups after treatment (P0.05). There were significant differences in uterine volume and myoma area between the two groups before and after treatment (P0.05). There was significant difference before and after treatment in AA group (P0.05). There was no significant difference between AG group and AG group before and after treatment (P0.05). Combined with the mean value, the effect of Jiawei Pingji decoction on reducing uterine volume, shrinking tumor and reducing integral of myoma in AA group was better than that in AG group. The curative effects were 73.3% and 33.33.3% in group A and group AG, 33.3% and 10.1% in group A and group AG, respectively, and 80% and 40% in group A and group AG, respectively. It can be seen that the group A can obviously improve the clinical symptoms and has a certain effect on reducing the area of leiomyoma, and the comprehensive effect of AA group is significantly better than that of AG group. Conclusion: Jiawei Pingji decoction can obviously improve the clinical symptoms, and at the same time, the effect of traditional Chinese medicine on strengthening and removing stasis and clearing away the interests and dispersing the knot, dispelling evil but not harming the right, to a certain extent, inhibits and delays the development of myoma, which has been proved by clinical practice. Through gene screening, before gene medicine is mature, Chinese medicine can better individual treatment for patients with uterine leiomyoma, reduce the economic burden of patients, it is very meaningful.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33
本文编号：2179539
[Abstract]:Objective: to observe the typing of ER 伪 gene rs9340799 locus (AA/AG type) in peripheral blood of patients with uterine leiomyoma. To evaluate the clinical effect of Jiawei Pingji decoction on the classification of ER 伪 gene rs9340799 locus (AA/AG type) in peripheral blood of patients with uterine leiomyoma. To investigate the relationship between the occurrence and development of uterine leiomyoma and the type of ER 伪 gene rs9340799 (AA/AG type). To explore the characteristics and advantages of Jiawei Pingji decoction in the treatment of uterine leiomyoma, to provide some references for the prevention and treatment of uterine leiomyoma with traditional Chinese medicine, and to evaluate the effective rate of Jiawei Pingji decoction for different genotyping of ER 伪 gene. So as to better guide the clinical treatment. Methods: sixty patients with uterine leiomyoma who met the inclusive criteria were treated with Jiawei Pingji decoction for 30 cases in pure (AA) group and 30 cases in heterozygous (AG) group. The course of treatment was 3 months after the end of the course of treatment. The changes of TCM syndrome score and uterine myoma volume before and after treatment were statistically analyzed. The result is 1: 1. The improvement of TCM syndromes score was improved in group A and AG (P0.05). After treatment, the score of TCM syndromes in group AA was lower than that in group AG, and the difference was statistically significant (P0.05). Uterine volume and myoma size, integral improvement: there was no significant difference in uterine volume, myoma area and myoma score between the two groups after treatment (P0.05). There were significant differences in uterine volume and myoma area between the two groups before and after treatment (P0.05). There was significant difference before and after treatment in AA group (P0.05). There was no significant difference between AG group and AG group before and after treatment (P0.05). Combined with the mean value, the effect of Jiawei Pingji decoction on reducing uterine volume, shrinking tumor and reducing integral of myoma in AA group was better than that in AG group. The curative effects were 73.3% and 33.33.3% in group A and group AG, 33.3% and 10.1% in group A and group AG, respectively, and 80% and 40% in group A and group AG, respectively. It can be seen that the group A can obviously improve the clinical symptoms and has a certain effect on reducing the area of leiomyoma, and the comprehensive effect of AA group is significantly better than that of AG group. Conclusion: Jiawei Pingji decoction can obviously improve the clinical symptoms, and at the same time, the effect of traditional Chinese medicine on strengthening and removing stasis and clearing away the interests and dispersing the knot, dispelling evil but not harming the right, to a certain extent, inhibits and delays the development of myoma, which has been proved by clinical practice. Through gene screening, before gene medicine is mature, Chinese medicine can better individual treatment for patients with uterine leiomyoma, reduce the economic burden of patients, it is very meaningful.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33
【参考文献】
相关期刊论文 前10条
1 王佳茵;张海珍;关云谦;周齐;;子宫肌瘤与雌激素受体α基因多态性关系的临床研究[J];北京医学;2010年11期
2 陈富强;汪爱萍;杨玉琴;范丽安;;雌激素受体基因多态性与子宫肌瘤的相关性研究[J];北京医学;2011年09期
3 叶琳;冯丽华;刘艳广;史杰萍;金花;王春华;隋春生;王树越;邓常玲;;雌激素受体α基因多态性与子宫肌瘤的关联性分析[J];吉林大学学报(医学版);2009年01期
4 官鑫;程熠;李勇;翁熹君;史杰萍;刘雅文;;雌激素受体α基因多态性与2型糖尿病的关联性分析[J];吉林大学学报(医学版);2011年05期
5 刘新敏;;李光荣教授运用活血药治疗妇科ve瘕经验[J];中华中医药杂志;2011年04期
6 牛艳丽;张丽君;庞志澜;;中药灌肠治疗子宫肌瘤疗效观察[J];中国医药导刊;2010年01期
7 陈富强;朱晓平;钱小虎;杨钰琴;范丽安;;雌激素受体基因多态性与子宫肌瘤的相关研究[J];中国妇产科临床杂志;2006年04期
8 孙淑芳,周琦;中药内服外用治疗子宫肌瘤105例[J];贵州医药;2003年09期
9 李万军;马新焕;王建良;;半夏的药理作用[J];西部中医药;2012年09期
10 袁红霞;张莉芹;马瑾;唐文茹;廖世奇;;水蛭药用成分及主要药理功效研究进展[J];甘肃医药;2013年04期
，本文编号：2179539
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2179539.html
最近更新
教材专著
