卡前列素氨丁三醇用于产后出血治疗的有效性与安全性分析

发布时间：2018-08-14 14:39

【摘要】：目的系统评价卡前列素氨丁三醇治疗产后出血的有效性和安全性。方法检索PubMed、Cochrane Library、EMbase数据库和中国知网、维普和万方数据库,收集卡前列素氨丁三醇(试验组)和缩宫素(对照组)治疗产后出血的随机对照试验(RCT)。提取年龄、用药方案、产后出血量和药物不良反应等数据并评价质量后,用RevMan 5.0软件进行统计分析。结果共纳入25项RCT,合计4503例患者(试验组2266例,对照组2237例)。Meta分析结果显示,术中出血量、产后2 h出血量、产后24 h出血量的均数差分别为=-75.62,-105.50,-116.89,试验组的出血量显著低于对照组,差异均有统计学意义(均P0.001);产后血红蛋白下降值的均数差-2.07,对照组的产后血红蛋白下降值显著低于试验组,差异有统计学意义(P0.001)。治疗后,试验组和对照组的出血发生率分别为8.94%(164/1834例)和18.38%(334/1817例),恶心呕吐发生率分别为13.73%(171/1245例)和8.70%(108/1241例),差异均有统计学意义(均P0.001)。结论卡前列素氨丁三醇治疗产后出血的效果明显优于缩宫素,且能减少出血发生率,但会增加恶心呕吐发生率。
[Abstract]:Objective to evaluate the efficacy and safety of carprostatin aminobutanol in the treatment of postpartum hemorrhage. Methods the database of PubMedus Cochrane Library EMbase, China knowledge Network, Weip and Wanfang were searched to collect carprost aminobutanol (trial group) and oxytocin (control group) in a randomized controlled trial (RCT).) for postpartum hemorrhage. The data of age, drug regimen, postpartum hemorrhage and adverse drug reactions were extracted and evaluated. The data were analyzed by RevMan 5.0 software. Results A total of 25 RCTs were included, totally 4503 patients (2266 cases in the trial group and 2237 cases in the control group). The results of Meta-analysis showed that the amount of intraoperative bleeding and the amount of blood loss at 2 hours postpartum were found. The mean difference of postpartum blood loss was -75.62- 105.50 ~ 116.89, which was significantly lower in the experimental group than that in the control group (all P 0.001), the mean difference of the postpartum hemoglobin decrease value was -2.07, the postpartum hemoglobin decreased value in the control group was significantly lower than that in the experimental group, and the mean value of the postpartum hemoglobin decrease value in the control group was significantly lower than that in the control group. The difference was statistically significant (P0.001). After treatment, the incidence of hemorrhage was 8.94% (164 / 1834 cases) and 18.38% (334 / 1817 cases), the incidence of nausea and vomiting was 13.73% (171 / 1245 cases) and 8.70% (108 / 1241 cases) in the trial group and control group, respectively (all P 0.001). Conclusion Carprostatin aminobutanol is superior to oxytocin in the treatment of postpartum hemorrhage, and can reduce the incidence of hemorrhage, but increase the incidence of nausea and vomiting.
【作者单位】：中国石油天然气集团公司中心医院药学部;中国石油天然气集团公司中心医院妇产科;中国石油天然气集团公司中心医院医务处;
【基金】：廊坊市科技计划支撑基金资助项目(2014013019)
【分类号】：R714.461

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