妊娠期碘营养状况及其与甲状腺功能关系研究
发布时间：2018-08-16 09:18
【摘要】：目的探讨广州地区孕妇碘营养状况及其与甲状腺功能的关系。方法选择2012年3月至2014年2月在中山大学孙逸仙纪念医院产检的孕妇815为研究对象,进行甲状腺功能、抗甲状腺过氧化物酶抗体(TPO-Ab)和尿碘的检测,结果异常者定期复查,密切监测母胎情况,追踪至妊娠终止。结果 815例无甲状腺疾病史孕妇尿碘中位数(median urinary iodine,MUI)为197.0μg/L;其中碘缺乏者39.6%(323/815);碘适宜者20.9%(170/815);碘超足量者27.4%(223/815);碘过量者12.1%(99/815)。早中晚孕期MUI分别为208、182.5、174.5μg/L。不同碘营养状况下甲状腺功能、甲状腺疾病的患病率及TPO-Ab阳性率的差异无统计学意义,均P0.05。结论孕妇碘营养状态为碘适宜,但个体间差异较大。不同碘营养状况下甲状腺疾病的患病率无明显差异,即轻度碘缺乏或碘过量不增加甲状腺疾病的患病率。随着孕周的增加,尿碘值逐渐下降,但都在碘适宜的范围内。
[Abstract]:Objective to investigate the iodine nutritional status of pregnant women in Guangzhou and its relationship with thyroid function. Methods from March 2012 to February 2014, 815 pregnant women in Sun Yat-sen Memorial Hospital, Sun Yat-sen University, were selected as subjects. Thyroid function, anti-thyroid peroxidase antibody (TPO-Ab) and urinary iodine were detected. Closely monitor the maternal and fetal conditions and follow up until the termination of pregnancy. Results the median urinary iodine (median urinary) of 815 pregnant women with no history of thyroid disease was 197.0 渭 g / L, in which 39.6% (32.3 / 815) were iodine deficient, 20.9% (170 / 815) were suitable for iodine, 27.4% (223815) were iodine excess, 12.1% (99r815) were iodine excess. The MUI of early, middle and late pregnancy was 208182.5174.5 渭 g / L, respectively. There was no significant difference in thyroid function, the prevalence of thyroid disease and the positive rate of TPO-Ab in different iodine nutrition status (P 0.05). Conclusion the iodine nutritional status of pregnant women is suitable for iodine, but there is great difference among individuals. There was no significant difference in the prevalence of thyroid diseases under different iodine nutrition conditions, that is, mild iodine deficiency or iodine excess did not increase the prevalence of thyroid diseases. With the increase of gestational weeks, urinary iodine values gradually decreased, but within the appropriate range of iodine.
【作者单位】： 中山大学附属第三医院妇产科;中山大学孙逸仙纪念医院妇产科;
【基金】：广东省科技计划(2011B031800119)
【分类号】：R714.256
本文编号：2185554
[Abstract]:Objective to investigate the iodine nutritional status of pregnant women in Guangzhou and its relationship with thyroid function. Methods from March 2012 to February 2014, 815 pregnant women in Sun Yat-sen Memorial Hospital, Sun Yat-sen University, were selected as subjects. Thyroid function, anti-thyroid peroxidase antibody (TPO-Ab) and urinary iodine were detected. Closely monitor the maternal and fetal conditions and follow up until the termination of pregnancy. Results the median urinary iodine (median urinary) of 815 pregnant women with no history of thyroid disease was 197.0 渭 g / L, in which 39.6% (32.3 / 815) were iodine deficient, 20.9% (170 / 815) were suitable for iodine, 27.4% (223815) were iodine excess, 12.1% (99r815) were iodine excess. The MUI of early, middle and late pregnancy was 208182.5174.5 渭 g / L, respectively. There was no significant difference in thyroid function, the prevalence of thyroid disease and the positive rate of TPO-Ab in different iodine nutrition status (P 0.05). Conclusion the iodine nutritional status of pregnant women is suitable for iodine, but there is great difference among individuals. There was no significant difference in the prevalence of thyroid diseases under different iodine nutrition conditions, that is, mild iodine deficiency or iodine excess did not increase the prevalence of thyroid diseases. With the increase of gestational weeks, urinary iodine values gradually decreased, but within the appropriate range of iodine.
【作者单位】： 中山大学附属第三医院妇产科;中山大学孙逸仙纪念医院妇产科;
【基金】：广东省科技计划(2011B031800119)
【分类号】：R714.256
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