孕早期孕妇妊娠相关血浆蛋白A与妊娠期糖尿病的相关性

发布时间：2018-08-16 10:57

【摘要】：目的探讨孕早期孕妇妊娠相关血浆蛋白A(PAPP-A)与妊娠期糖尿病(GDM)的相关性及临床意义。方法 2015年2月至2016年7月共有15 268例孕妇在广州市妇女儿童医疗中心分娩,经筛选后,在我院行一站式唐氏筛查且数据完整的孕妇共5 632例作为研究对象,其中GDM孕妇873例(GDM组),非GDM孕妇4 759例(对照组)。参照美国糖尿病协会(ADA)2014年发布的指南确立GDM的诊断标准,抽取孕妇静脉血,采用酶联免疫吸附法(ELISA)检测GDM孕妇与非GDM孕妇PAPP-A中位数值(Mo M)的水平。结果 GDM组孕妇血清PAPP-A值水平较对照组低(P0.000 1),且PAPP-A水平与GDM相关(P0.000 1)。受试者操作特征曲线(ROC)分析发现能够诊断GDM的PAPP-A的Mo M值为1.06,曲线下面积(AUC)为0.565(P0.000 1)。结论 PAPP-A与GDM相关,孕早期低PAPP-A值增加患GDM的风险;PAPP-A有望应用于GDM的早期预测。
[Abstract]:Objective to investigate the relationship between pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes mellitus (GDM) and its clinical significance. Methods from February 2015 to July 2016, a total of 15 268 pregnant women were given birth in Guangzhou Women and Children Medical Center. After screening, 5 632 pregnant women with complete data were screened in our hospital. There were 873 GDM pregnant women (GDM group) and 4 759 non GDM pregnant women (control group). According to the guidelines issued by the American Diabetes Association (ADA) in 2014 to establish the diagnostic criteria for GDM, the venous blood samples were drawn from pregnant women and the median PAPP-A (Mo M) level of GDM pregnant women and non-GDM pregnant women was detected by (ELISA) with enzyme linked immunosorbent assay (Elisa). Results the level of serum PAPP-A in GDM group was lower than that in control group (P0.000 1), and the level of PAPP-A was correlated with GDM (P0.000 1). (ROC) analysis of the operating characteristic curve showed that the Mo M value of PAPP-A and the area under the curve (AUC) were 1.06 and 0.565 (P0.0001), respectively. Conclusion PAPP-A is associated with GDM. Low PAPP-A value in early pregnancy may increase the risk of GDM. PAPP-A may be used in early prediction of GDM.
【作者单位】：广州市妇女儿童医疗中心妇幼与计划生育信息部;广州市妇女儿童医疗中心产科;
【分类号】：R714.256

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