乙肝疫苗联合乙肝免疫球蛋白阻断乙肝母婴垂直传播的疗效及影响因素研究

发布时间：2018-08-16 14:32

【摘要】：目的探讨乙肝疫苗联合乙肝免疫球蛋白阻断乙肝母婴垂直传播的临床疗效及影响因素。方法选取2012年6月—2014年6月江山市人民医院收治的HBsAg阳性孕妇及其所产新生儿,各80例。新生儿出生后24 h注射乙肝免疫球蛋白(HBIG),并按"0-1-6"程序进行乙肝疫苗接种。检测新生儿的HBsAg和HBs Ab,比较不同喂养方式、分娩方式、产妇"大三阳"http://www.cnki.com.cn/"小三阳"情况及产妇孕前是否按程序接种HBIG新生儿的HBsAg阳性率。结果80例新生儿中,HBsAg阳性6例,阳性率为7.5%;HBs Ab阳性45例,阳性率56.3%。不同喂养方式、分娩方式及产妇孕前是否按程序接种HBIG新生儿的HBsAg阳性率比较,差异无统计学意义(P0.05);产妇为"大三阳"新生儿的HBsAg阳性率高于产妇为"小三阳"的新生儿(P0.05)。结论乙肝疫苗联合HBIG能够降低HBV的母婴垂直传播率,孕妇"大三阳"http://www.cnki.com.cn/"小三阳"情况是新生儿HBsAg阳性率的影响因素。
[Abstract]:Objective to investigate the clinical efficacy and influencing factors of hepatitis B vaccine combined with hepatitis B immunoglobulin in blocking vertical transmission of hepatitis B from mother to child. Methods 80 cases of HBsAg positive pregnant women and their newborns were selected from June 2012 to June 2014 in Jiangshan people's Hospital. Hepatitis B immunoglobulin (HBIG),) was injected 24 hours after birth and inoculated according to "0-1-6" procedure. The HBsAg and HBs abs of newborns were detected, and the different feeding methods, delivery methods, the situation of "big three positive" http://www.cnki.com.cn/ "small three positive women" and the positive rate of HBsAg of pregnant women who were inoculated with HBIG before pregnancy were compared. Results among the 80 newborns, 6 cases were HBsAg positive, the positive rate was 7.5% and 45 cases were positive for HBs Ab, the positive rate was 56.3%. There was no significant difference in HBsAg positive rate of newborn infants with HBIG inoculated by procedure before delivery and delivery mode (P0.05), and the positive rate of HBsAg in newborns with "big three positive" pregnant women was higher than that of newborns with "small three positive" pregnant women (P0.05). Conclusion Hepatitis B vaccine combined with HBIG can reduce the vertical transmission rate of HBV from mother to child. The positive rate of HBsAg in neonates is influenced by the condition of "Big three positive" and "small three positive" of http://www.cnki.com.cn/ in pregnant women.
【作者单位】：浙江省江山市人民医院;
【分类号】：R714.251

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