血清糖类抗原CA125和CA19-9对鉴别卵巢交界性肿瘤及上皮性卵巢癌的价值
发布时间：2018-08-19 09:02
【摘要】：目的探讨血清糖类抗原(carbohydrate antigen,CA)125、CA19-9对卵巢交界性肿瘤(borderline ovarian tumor,BOT)及上皮性卵巢癌(epithelial ovarian cancer,EOC)的诊断价值。方法以术后组织病理为金标准,180例卵巢上皮性肿瘤患者中60例BOT者为BOT组,120例EOC者为EOC组。比较2组患者血清CA125、CA19-9水平与其临床病理特征。结果 EOC组血清CA125水平(361.75u/mL)高于BOT组(17.61u/mL)(P0.01),EOC组和BOT组血清CA19-9水平(10.20、10.26u/mL)比较差异无统计学意义(P0.05);CA125、CA19-9鉴别BOT、EOC的AUC分别是0.850(95%CI:0.794~0.907,P=0.000)、0.448(95%CI:0.363~0.533,P=0.078),当CA125的cut-off值为51.21u/mL时,其敏感性、特异度、阳性预测值、阴性预测值、阳性似然比、阴性似然比分别为80%、80%、88.9%、66.7%、4.00、0.25,CA125鉴别BOT、EOC的准确性为80%;浆液性EOC、浆液性肿瘤(包括BOT、EOC)的CA125阳性率(88.2%、73.0%)高于CA19-9(18.6%、17.7%)(P0.05);浆液性肿瘤的CA125阳性率(73.0%)高于黏液性肿瘤(30.8%),黏液性肿瘤的CA19-9阳性率(34.6%)高于浆液性肿瘤(17.7%)(P0.05)。结论当CA12551.21u/mL,对EOC和BOT的鉴别诊断有重要价值,而CA19-9对其鉴别无意义。
[Abstract]:Objective to investigate the diagnostic value of serum carbohydrate antigen 125 (CA19-9) in the diagnosis of ovarian borderline tumor (borderline ovarian tumor bot) and epithelial ovarian cancer (epithelial ovarian cancer-EOC). Methods among 180 cases of ovarian epithelial tumor, 60 cases of BOT were BOT group and 120 cases of EOC group were EOC group. The serum CA125 and CA19-9 levels and their clinicopathological features were compared between the two groups. 缁撴灉 EOC缁勮娓匔A125姘村钩(361.75u/mL)楂樹簬BOT缁，
本文编号：2191189
[Abstract]:Objective to investigate the diagnostic value of serum carbohydrate antigen 125 (CA19-9) in the diagnosis of ovarian borderline tumor (borderline ovarian tumor bot) and epithelial ovarian cancer (epithelial ovarian cancer-EOC). Methods among 180 cases of ovarian epithelial tumor, 60 cases of BOT were BOT group and 120 cases of EOC group were EOC group. The serum CA125 and CA19-9 levels and their clinicopathological features were compared between the two groups. 缁撴灉 EOC缁勮娓匔A125姘村钩(361.75u/mL)楂樹簬BOT缁，
本文编号：2191189
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