营养与子痫前期关系的病例对照研究
发布时间：2018-08-20 16:23
【摘要】：目的探讨子痫前期(Preeclampsia,PE)的发生与饮食习惯、膳食摄入及血生化指标的关系,为指导孕期合理膳食、纠正不良生活习惯及预防子痫前期的发生提供理论依据。方法收集2016年3月至2016年12月在郑州大学第一附属医院产科住院分娩的PE患者167例为病例组,按照年龄±3岁、孕周±2周,随机选取同月份住院分娩的血压正常孕妇167例作为对照组,采用自编的《孕期健康危险因素评估问卷》调查病例组及对照组的社会人口学统计资料、近三个月膳食摄入情况及相关的实验室检查结果,运用Epidata3.1进行资料的录入,SPSS17.0建立数据库并进行统计分析,检验水准α=0.05。结果:1.病例组与对照组在分娩孕周、身高、分娩体重、孕前BMI、孕期体重变化(包括早、中、晚期)、高血压家族史、产次、孕次、文化程度及饮食口味上差异有统计学意义(P0.05),经非条件logistic回归分析发现孕前BMI[OR=1.28(95%CI1.13~1.45)]、孕次[OR=0.33(95%CI0.17~0.68)]、高血压家族史[OR=2.30(95%CI1.31~4.04)]及文化程度[OR=0.38(95%CI0.20~0.73)]与PE的发病风险有关。2.病例组各食物成分及营养素摄入量普遍低于对照组,尤其是在薯类、水果、禽畜肉类、蛋白质、各种维生素及矿物质的摄入量上差异有统计学意义(P0.05),经logistic回归分析发现,薯类[OR=0.86(95%CI0.75~0.98)]、畜禽肉类[OR=0.86(95%CI0.75~0.99)]、维生素C[OR=0.87(95%CI0.75~0.99)]及锌[OR=0.67(95%CI0.48~0.93)]的摄入量可能是PE的保护因素。3.两组人群国际膳食质量指数(Dietary quality index-international,DQI-I)较低,病例组评分低于对照组(P0.05),经logistic回归分析发现,DQI-I得分是PE发病的保护因素[OR=0.82(95%CI0.71~0.96)]。4.两组孕妇血生化指标差异也存在统计学意义(P0.05),经过多因素logistic回归分析发现,血清白蛋白[OR=0.40(95%CI0.26~0.63)]、钾[OR=1.48(95%CI1.20~1.81)]、镁[OR=1.24(95%CI1.08~1.41)]及血红蛋白[OR=2.26(95%CI 1.71~2.99)]水平与PE发病风险有关。结论:1.孕前BMI、高血压家族史可能为PE的危险因素,而孕次"f3次、文化程度可能为PE的保护因素。2.薯类、畜禽肉类、维生素C及锌的摄入量可能为PE的保护因素。3.国际膳食质量指数得分可能为PE的保护因素。4.血清钾、镁及血红蛋白水平可能为PE的危险因素,而血清白蛋白水平可能为PE的保护因素。
[Abstract]:Objective to explore the relationship between preeclampsia PE and dietary habits, dietary intake and blood biochemical indexes, so as to provide theoretical basis for guiding reasonable diet during pregnancy, correcting bad living habits and preventing preeclampsia. Methods from March 2016 to December 2016, 167 cases of PE patients who were hospitalized and delivered in obstetrics department of the first affiliated Hospital of Zhengzhou University were collected as the case group, according to age 卤3 years, gestational week 卤2 weeks. 167 normal pregnant women with normal blood pressure during the same month were randomly selected as the control group. The social demographic statistics of the case group and the control group were investigated by the self-designed questionnaire on risk factors of pregnancy. In the last three months, dietary intake and related laboratory examination results were used to establish the database with Epidata3.1 data input and SPSS 17.0, and the test level was 0. 05%. The result is 1: 1. The case group and the control group had a family history of hypertension, birth, pregnancy, BMIs before pregnancy, changes in weight during pregnancy (including early, middle, and late), family history of hypertension, delivery, pregnancy. There were significant differences in educational level and dietary taste (P0.05). BMI [OR=1.28 (95%CI1.13~1.45)], OR=0.33 (95%CI0.17~0.68), OR=2.30 (95%CI1.31~4.04) and education (OR=0.38 (95%CI0.20~0.73) were found to be associated with PE risk by non-conditional logistic regression analysis. The intake of food components and nutrients in the case group was generally lower than that in the control group, especially in potato, fruit, livestock meat, protein, various vitamins and minerals (P0.05), which were found by logistic regression analysis. The intake of OR=0.86 (95%CI0.75~0.98), OR=0.86 (95%CI0.75~0.99), OR=0.87 (95%CI0.75~0.99) and OR=0.67 (95%CI0.48~0.93) may be the protective factors of PE. The international dietary quality index (Dietary quality index-international DQI-I) of the two groups was lower than that of the control group (P0.05). The logistic regression analysis showed that the DQI-I score was the protective factor of PE [OR=0.82 (95%CI0.71~0.96)] .4. There was also significant difference in serum biochemical indexes between the two groups (P0.05). The levels of serum albumin [OR=0.40 (95%CI0.26~0.63)], potassium [OR=1.48 (95%CI1.20~1.81)], magnesium [OR=1.24 (95%CI1.08~1.41)] and hemoglobin [OR=2.26 (95%CI 1.71 卤2.99)] were correlated with the risk of PE by multivariate logistic regression analysis. Conclusion 1. BMI before pregnancy, hypertension family history may be the risk factor of PE, and pregnant "f 3 times, education level may be the protective factor of PE. 2." The intake of potato, meat, vitamin C and zinc may be the protective factor of PE. The score of international dietary quality index may be the protective factor of PE. The levels of serum potassium, magnesium and hemoglobin may be the risk factors of PE, while serum albumin may be the protective factor of PE.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.244
[Abstract]:Objective to explore the relationship between preeclampsia PE and dietary habits, dietary intake and blood biochemical indexes, so as to provide theoretical basis for guiding reasonable diet during pregnancy, correcting bad living habits and preventing preeclampsia. Methods from March 2016 to December 2016, 167 cases of PE patients who were hospitalized and delivered in obstetrics department of the first affiliated Hospital of Zhengzhou University were collected as the case group, according to age 卤3 years, gestational week 卤2 weeks. 167 normal pregnant women with normal blood pressure during the same month were randomly selected as the control group. The social demographic statistics of the case group and the control group were investigated by the self-designed questionnaire on risk factors of pregnancy. In the last three months, dietary intake and related laboratory examination results were used to establish the database with Epidata3.1 data input and SPSS 17.0, and the test level was 0. 05%. The result is 1: 1. The case group and the control group had a family history of hypertension, birth, pregnancy, BMIs before pregnancy, changes in weight during pregnancy (including early, middle, and late), family history of hypertension, delivery, pregnancy. There were significant differences in educational level and dietary taste (P0.05). BMI [OR=1.28 (95%CI1.13~1.45)], OR=0.33 (95%CI0.17~0.68), OR=2.30 (95%CI1.31~4.04) and education (OR=0.38 (95%CI0.20~0.73) were found to be associated with PE risk by non-conditional logistic regression analysis. The intake of food components and nutrients in the case group was generally lower than that in the control group, especially in potato, fruit, livestock meat, protein, various vitamins and minerals (P0.05), which were found by logistic regression analysis. The intake of OR=0.86 (95%CI0.75~0.98), OR=0.86 (95%CI0.75~0.99), OR=0.87 (95%CI0.75~0.99) and OR=0.67 (95%CI0.48~0.93) may be the protective factors of PE. The international dietary quality index (Dietary quality index-international DQI-I) of the two groups was lower than that of the control group (P0.05). The logistic regression analysis showed that the DQI-I score was the protective factor of PE [OR=0.82 (95%CI0.71~0.96)] .4. There was also significant difference in serum biochemical indexes between the two groups (P0.05). The levels of serum albumin [OR=0.40 (95%CI0.26~0.63)], potassium [OR=1.48 (95%CI1.20~1.81)], magnesium [OR=1.24 (95%CI1.08~1.41)] and hemoglobin [OR=2.26 (95%CI 1.71 卤2.99)] were correlated with the risk of PE by multivariate logistic regression analysis. Conclusion 1. BMI before pregnancy, hypertension family history may be the risk factor of PE, and pregnant "f 3 times, education level may be the protective factor of PE. 2." The intake of potato, meat, vitamin C and zinc may be the protective factor of PE. The score of international dietary quality index may be the protective factor of PE. The levels of serum potassium, magnesium and hemoglobin may be the risk factors of PE, while serum albumin may be the protective factor of PE.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.244
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