去氧孕烯炔雌醇片加米非司酮联合归脾丸治疗绝经过渡期功能性子宫出血的效果

发布时间：2018-08-20 17:23

【摘要】：目的比较不同给药方案对绝经过渡期功能性子宫出血(功血)患者的影响。方法将收治的146例绝经过渡期功血患者依据用药方案差异分组,其中72例仅给予米非司酮和去氧孕烯炔雌醇片治疗设为对照组,其余74例采用去氧孕烯炔雌醇片加米非司酮配合归脾丸治疗设为观察组,比较两组疗效与不良反应。结果两组总有效率分别为93.24%与80.55%,观察组疗效明显更理想(P0.05);观察组出血时间[(28.4±5.3)h]与控制时间[(27.9±1.4)d]、突破性出血的发生率(5.41%)均明显低于对照组的血时间[(32.9±4.4)h]与控制时间[(29.6±1.7)d]、突破性出血的发生率(16.67%)(P0.05),观察组2例(2.70%)出现轻微恶心,未作任何特殊处理病症自行缓解。对照组9例(12.50%)出现恶心、头晕与食欲不振症状,停药后症状自行缓解。两组不良反应发生率差异有统计学意义(醊2=5.03,P0.05)。结论给予绝经过渡期功血患者采用去氧孕烯炔雌醇片加米非司酮配合归脾丸治疗,疗效确切且安全。
[Abstract]:Objective to compare the effects of different administration regimens on functional uterine bleeding in menopausal transitional period. Methods 146 cases of postmenopausal transitional dysfunctional patients were divided into two groups according to the difference of medication scheme. 72 cases were treated with mifepristone and deoxypregnenes estradiol only as control group. The other 74 cases were treated with deoxypregnenes estradiol tablet and mifepristone combined with Guipi Pill as observation group. The curative effect and adverse reaction were compared between the two groups. Results the total effective rates of the two groups were 93.24% and 80.55, respectively. The curative effect of the observation group was significantly better than that of the control group (P0.05), the bleeding time and the control time in the observation group [(28.4 卤5.3) h] and the control time [(27.9 卤1.4) d], the incidence of breakthrough hemorrhage (5.41%) were significantly lower than those in the control group [(32.9 卤4.4) h] and (29.6 卤1.7) d, respectively, and the breakthrough time was significantly lower than that in the control group [(32.9 卤4.4) h and (29.6 卤1.7) d]. The incidence of sexual hemorrhage was 16.67% (P0.05). In the observation group, 2 cases (2.70%) developed slight nausea. No special treatment was given to relieve the disease. In the control group, 9 cases (12.50%) developed nausea, dizziness and anorexia. There was significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion it is safe and effective to treat patients with postmenopausal transitional dysfunctional patients with deoxypregnenyl estradiol and mifepristone combined with Guipi Pill.
【作者单位】：河南省南阳市中心医院妇产科;
【分类号】：R711.52

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