南宁市妇女人乳头状病毒感染状态及危险因素调查

发布时间：2018-08-20 19:23

【摘要】：目的调查南宁市妇女高危型人乳头状病毒(HPV)感染状态及危险因素。方法 2014年1~6月,在该院妇科门诊就诊自愿参加进行宫颈癌机会性筛查及问卷调查的妇女431名为研究对象,收集她们的人口学信息和相关危险因素信息,并行常规妇科检查、生殖道微生物检测、宫颈细胞第2代杂交捕获技术(HC2)检测、细胞学检查。对可疑宫颈上皮内瘤变或宫颈癌患者行阴道镜检查活检,并进行组织病理学诊断。结果 431名调查对象中,高危型HPV感染54例,感染率12.53%。在宫颈病变组与宫颈正常组中,高危型HPV阳性率分别为87.50%和9.64%,两者比较差异有统计学意义(P0.05)。单因素及多因素研究分析,多个性伴侣(≥2个)和病原菌感染(尤其是细菌性阴道炎)是高危型HPV感染的高危因素。对阴道微生态环境的多因素分析显示,病原菌感染和细菌性阴道病是HPV病毒感染的高危因素。结论宫颈病变组中HPV感染率高于宫颈正常组,而初次性生活年龄早、多个性伴侣、病原菌感染、细菌性阴道病是HPV感染的危险因素。
[Abstract]:Objective to investigate the status and risk factors of high-risk human papillary virus (HPV) infection in women in Nanning. Methods from January to June 2014, 431 women who volunteered to take part in the chance screening and questionnaire survey of cervical cancer in gynecological outpatient clinic of our hospital were selected as study subjects. Their demographic information and related risk factors were collected, and routine gynecological examinations were performed. Genital tract microorganism detection, cervical cell second generation hybridization capture technique (HC2) detection, cytological examination. Colposcopy biopsy and histopathological diagnosis were performed in patients with suspected cervical intraepithelial neoplasia or cervical cancer. Results among 431 subjects, 54 cases were high risk HPV infection, the infection rate was 12.53%. The positive rates of high-risk HPV were 87.50% and 9.64 in cervical lesion group and normal cervical group respectively, the difference was statistically significant (P0.05). Univariate and multivariate analysis showed that multiple personality partners (鈮，

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