2318例人乳头瘤病毒基因分型及相关因素的分析

发布时间：2018-08-20 19:59

【摘要】：目的:探讨宫颈门诊就诊人群中人乳头瘤病毒型别分布及其与年龄、季节相关性并分析病毒清除所需时间,为宫颈疾病防治提供理论依据。方法:回顾性分析南京鼓楼医院妇科宫颈门诊2318例妇女,自愿行HPV分型结果,探讨HPV感染与年龄及季节的相关性,并挑选其中首次发现HPV阳性,3月后定期复查HPV分型直至分型转阴,分析其HPV清除所需时间。结果:1、2318例行HPV分型检测结果:阴性908例,阳性1410例(60.83%),高危HPV感染型别主要为:HPV16、58、52、31、53及HPV33,低危HPV感染型别主要为 HPV81(CP8304)、11及HPV6;2、高危HPV在各年龄组中阳性率不同,1)≤30岁组共537例,高危HPV阳性 285 例(53.07%);2)31-40 岁组共 791 例,高危 HPV 阳性 431 例(54.49%);3)41-50岁组共642例,高危HPV阳性346例(53.89%);4)51-60岁组共272例,高危HPV阳性121例(44.49%);5)≥61岁组共76例,高危HPV阳性28例(36.84%)。经各组间高危HPV阳性率比较发现,≤30岁组、31-40岁组、41-50岁组,分别与51-60岁组、≥61岁组差异具有统计学意义,其余差异无统计学意义;3、在不同季节中高危HPV检出率不同:春季共766例,高危HPV检出阳性442例(57.70%);夏季共628例,高危HPV检出阳性356例(56.69%);秋季共413例,高危HPV检出阳性228例(55.21%);冬季共511例,高危HPV检出阳性254例(49.71%),各季节间高危HPV检出率比较发现,冬季高危HPV检出率分别与春季、夏季间高危HPV检出率比较,P0.05,差异有统计学意义,其余季节间差异无统计学意义;4、四个季节中HPV型别检出情况:1)春季主要检出HPV型别:HPV16(12.92%、HPV58(12.14%)、HPV52(9.92%),HPV31(7.31%);2)夏季主要检出 HPV型别:HPV16(16.88%),HPV58(9.55%),HPV52(9.39%),HPV18(6.69%);3)秋季主要检出HPV型别:HPV16(16.22%),HPV58、HPV52(各10.65%),HPV33(6.30%),HPV18(4.73%);4)冬季主要检出 HPV 型别:HPV16(10.57%),HPV58(10.18%),HPV52(8.81%),HPV31、HPV53(各5.68%);5、在研究对象中挑选首次发现HPV阳性,3月后定期复查HPV分型直至HPV分型转阴的妇女共99例,72例高危HPV感染其平均清除时间268.53天,其中HPV16平均清除时间272.23天。27例低危HPV感染其平均清除时间219.19天。99例HPV感染妇女中超过50%其病毒清除时间为3-12个月,中位清除时间为182 天。结论:1、南京鼓楼医院宫颈门诊就诊人群中高危HPV感染主要型别为:HPV16、58、52、31、53 及 HPV33;低危 HPV 型别为:HPV81(CP8304)、11 及 HPV6;2、高危HPV感染在各年龄组中有所不同,≤50岁高危HPV感染比例较高,51岁以后略有下降;3、高危HPV在各季节中阳性检出率存在差异:春季、夏季高危HPV检出率分别高于冬季,其余季节间无差异;4、各季节中高危HPV感染型别略有差异,HPV16/58/52是所有季节都常见的高危型别,除以上型别外,HPV31在春季较常见,HPV18在夏季常见,HPV33在秋季常见;5、本研究中HPV阳性并定期复查分型妇女中超过50%其病毒清除时间为3-12个月,中位清除时间为182天。
[Abstract]:Objective: to study the distribution of human papillomavirus (HPV) type and its correlation with age, season and time of virus clearance in cervical outpatient population, and to provide theoretical basis for the prevention and treatment of cervical diseases. Methods: the results of HPV typing in 2318 women from gynecologic cervical outpatient department of Nanjing Gulou Hospital were analyzed retrospectively, and the correlation between HPV infection and age and season was discussed. The HPV positive was found for the first time, and the time of HPV clearance was analyzed by reviewing HPV typing regularly until the type turned negative 3 months later. Results the results of HPV typing were as follows: 908 cases were negative, 1410 cases were positive (60.83%). The main types of high risk HPV infection were HPV16582O31C53 and HPV33.The low risk HPV infection types were HPV81 (CP8304) 11 and HPV62.The positive rate of high risk HPV in different age group (1) 鈮，

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