妊娠期高血压疾病患者血浆氨基末端脑钠尿肽前体及高敏C反应蛋白与疾病严重程度的相关性

发布时间：2018-08-23 12:18

【摘要】：目的探讨妊娠期高血压疾病(HDCP)患者血浆氨基末端脑钠尿肽前体(NT-proBNP)及高敏C反应蛋白(hsCRP)与疾病严重程度的关系。方法选取2012年3月至2014年6月97例因妊娠期间初发高血压就诊患者为研究对象,按入院时病情分为重度子痫前期组(重度子痫前期患者33例)和非重度子痫前期组(妊娠高血压及轻度子痫前期患者64例),另外选取同期同孕周正常健康妊娠妇女60人为对照组。记录孕妇收缩压及舒张压水平,检测孕妇血浆NT-proBNP、hsCRP;将HDCP孕妇血浆NT-proBNP、hsCRP按照中位数分为两组,比较各组出现不同病情高血压疾病的构成比。结果与对照组比较,重度子痫前期组及非重度子痫前期组孕妇的血浆NT-proBNP、hsCRP水平、24h定量尿蛋白、收缩压、舒张压较高(均P0.05),但重度子痫前期组与非重度子痫前期组间上述指标水平的差异无统计学意义(P0.05)。与NT-proBNP≤263.6ng/L组比较,NT-proBNP263.6ng/L组孕妇hsCRP水平较高(P0.05),重度子痫前期构成比亦较高(P0.05);与hsCRP≤6.83 mg/L组比较,hsCRP6.83mg/L组孕妇血浆NT-proBNP水平较高(P0.05),重度子痫前期构成比亦较高(P0.05)。结论 HDCP患者血浆NT-proBNP、hsCRP水平随着病情发展不断升高,与重度子痫的发生密切相关。
[Abstract]:Objective to investigate the relationship between plasma amino-terminal brain natriuretic peptide precursor (NT-proBNP) and Gao Min C-reactive protein (Gao Min C reactive protein (hsCRP) and severity of hypertensive disorder complicating pregnancy (HDCP). Methods from March 2012 to June 2014, 97 patients with primary hypertension during pregnancy were selected as subjects. The patients were divided into severe preeclampsia group (33 patients with severe preeclampsia) and non-severe preeclampsia group (64 patients with pregnancy-induced hypertension and mild preeclampsia). 60 female as control group. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded, plasma NT-proBNPhsCRP was measured, and plasma NT-proBNPhsCRP was divided into two groups according to median. Results compared with the control group, the plasma NT-proBNPhsCRP levels of pregnant women in severe preeclampsia group and non-severe preeclampsia group were determined by 24 h quantitative urine protein and systolic blood pressure (SBP). Diastolic blood pressure was higher (P0.05), but there was no significant difference between severe preeclampsia group and non-severe preeclampsia group (P0.05). Compared with NT-proBNP 鈮，

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