NT-proBNP与炎症因子在先兆子痫的诊疗价值及临床意义

发布时间：2018-08-23 20:07

【摘要】：目的探讨NT-proBNP与炎症因子对先兆子痫的诊疗价值及临床意义。方法选取该院2015年2月至2016年2月正常妊娠孕妇81例为A组,轻度先兆子痫患者81例为B组,重度先兆子痫患者81例为C组,行NT-proBNP与炎症因子检测。比较各组NT-proBNP与炎症因子差异,分析NT-proBNP、炎症因子与先兆子痫的相关性。结果治疗前NT-proBNP、C反应蛋白(CRP)、白细胞介素(IL)-6、肿瘤坏死因子α(TNF-α)比较,从高到低为C、B、A组(P0.05)。治疗后,B组与C组NTproBNP、CRP、IL-6、TNF-α降低(P0.05)。治疗后NT-proBNP、CRP、IL-6、TNF-α比较,从高到低为C、B、A组(P0.05)。NT-proBNP、CRP、IL-6、TNF-α与先兆子痫呈正相关(r=0.569、0.602、0.418、0.427,P=0.000)。并发症发生率比较,从高到低为C、B、A组(P0.05)。结论先兆子痫患者NT-proBNP与炎症因子有升高趋势,可将其作为先兆子痫评价的有效指标。
[Abstract]:Objective to investigate the value and clinical significance of NT-proBNP and inflammatory factors in the diagnosis and treatment of preeclampsia. Methods from February 2015 to February 2016, 81 pregnant women with normal pregnancy were selected as group A, 81 patients with mild preeclampsia as group B and 81 patients with severe preeclampsia as group C. NT-proBNP and inflammatory factors were detected. To compare the difference between NT-proBNP and inflammatory factors, and to analyze the correlation between NT-proBNP, inflammatory factors and preeclampsia. Results before treatment, NT-proBNP,C reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor 伪 (TNF- 伪) were compared between the two groups (P 0.05). After treatment, NTproBNP,CRP,IL-6,TNF- 伪 decreased in group B and group C (P0.05). After treatment, there was a positive correlation between NT-proBNP,CRP,IL-6,TNF- 伪 and preeclampsia (P 0.05). NT-proBNPP CRP6 TNF- 伪 was positively correlated with preeclampsia (r = 0.569, 0.602, 0.418 ~ 0.427, P ~ (0.000). The incidence of complications was compared from high to low in group A (P 0.05). Conclusion NT-proBNP and inflammatory factors in patients with preeclampsia have an increasing tendency and can be used as an effective index for the evaluation of preeclampsia.
【作者单位】：河北省唐山市妇幼保健院内科;
【分类号】：R714.244

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