卵巢浆液性腺癌BRMS1、RIZ1和SATB1蛋白表达及其与预后的关系

发布时间：2018-08-26 14:04

【摘要】：目的探讨卵巢低、高级别浆液性腺癌中BRMS1、RIZ1和SATB1蛋白表达及其临床病理意义。方法应用免疫组化Eli Vision法检测卵巢低、高级别浆液性腺癌组织中BRMS1、RIZ1和SATB1蛋白的表达,对比分析三者在不同级别浆液性腺癌中的表达规律,并应用Kaplan-Meier单因素统计法分析三者与不同级别浆液性腺癌患者预后的关系。结果 BRMS1、RIZ1和SATB1蛋白在高级别组中的阳性率分别为43.9%、46.3%和51.2%;与对照组相比,BRMS1、RIZ1的表达明显降低,而SATB1明显升高(P0.05)。低级别组中三者的阳性率分别为30.0%、35.0%和75.0%;交界性囊腺瘤中分别为55.6%、50.0%和55.6%;与对照组和囊腺瘤组比较,BRMS1、RIZ1的表达明显降低,而SATB1明显升高(P0.05)。BRMS1、RIZ1和SATB1在低、高级别浆液性腺癌中的表达差异无显著性(P0.05)。Kaplan-Meier单因素统计分析结果显示,高级别组BRMS1和RIZ1阳性患者3、5年生存率明显高于阴性患者,而SATB1阳性患者生存率明显低于阴性患者(P0.05)。低级别组中二者未见明显差异(P0.05)。结论 BRMS1和RIZ1表达降低,SATB1表达升高,它们既参与了高级别浆液性腺癌,也参与了低级别浆液性腺癌的发生,提示不同级别浆液性腺癌的发生仍然存在一些相同的分子改变。三者表达与高级别浆液性腺癌的预后有关,而与低级别浆液性腺癌无关。
[Abstract]:Objective to investigate the expression of BRMS1,RIZ1 and SATB1 protein and its clinicopathological significance in ovarian low and high grade serous adenocarcinoma. Methods Immunohistochemical Eli Vision method was used to detect the expression of BRMS1,RIZ1 and SATB1 in low-grade and high-grade serous adenocarcinoma of ovary. The relationship between the three factors and the prognosis of patients with serous adenocarcinoma was analyzed by Kaplan-Meier single factor statistics. Results the positive rates of BRMS1,RIZ1 and SATB1 protein in high grade group were 46.3% and 51.2%, respectively, and the expression of RIZ1 was significantly lower than that of control group (P0.05). The positive rates of BRMS1 and RIZ1 were 30.0% and 75.0% in the low grade group, 55.6% and 55.6% in the borderline cystadenoma, respectively. The expression of BRMS1 and RIZ1 in the borderline cystadenoma was significantly lower than that in the control group and the cystadenoma group, while the expression of BRMS1 RIZ1 and SATB1 was significantly increased (P0.05). BRMS1 RIZ1 and SATB1 were significantly higher in the lower grade group than in the control group and the cystadenoma group. There was no significant difference in the expression of high grade serous adenocarcinoma (P0.05). Kaplan-Meier single factor statistical analysis showed that the 3- and 5-year survival rate of BRMS1 and RIZ1 positive patients in high grade group was significantly higher than that of negative patients, while the survival rate of SATB1 positive patients was significantly lower than that of negative patients (P0.05). There was no significant difference between the two groups (P0.05). Conclusion the expression of BRMS1 and RIZ1 decreased and the expression of SATB1 increased. They were involved in both high grade serous adenocarcinoma and low grade serous adenocarcinoma, suggesting that there are still some same molecular changes in the occurrence of different grade serous adenocarcinoma. Their expression was related to the prognosis of high grade serous adenocarcinoma, but not to low grade serous adenocarcinoma.
【作者单位】：河北医科大学第四医院妇科;河北医科大学第二医院病理科;
【基金】：河北省自然科学基金(C2009001229)
【分类号】：R737.31

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