既往自然流产次数与患者第3日胚胎质量的关系研究

发布时间：2018-08-31 17:58

【摘要】：目的:探讨既往自然流产次数与患者第3日胚胎质量的关系。方法:回顾性分析因单纯输卵管因素或盆腔粘连原因行第1周期体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)治疗的患者资料,排除已知的影响流产和胚胎发育疾病的患者,将患者按流产次数分为4组,分别为既往自然流产次数0次组(n=1 252)、1次组(n=385)、2次组(n=77)和≥3次组(n=36)。结果:第3日的优质胚胎率和受精率各组间比较均有统计学差异(P0.05);既往自然流产0次、1次、2次组的优质胚胎率随流产次数增加呈下降趋势(P=0.005);但既往自然流产≥3次组的优质胚胎率和受精率较2次自然流产组均有升高趋势,进一步分析患者临床资料显示,既往自然流产≥3次的患者在IVF-ET前进行全面的自然流产原因筛查和治疗的比例显著高于2次自然流产组,差异具有统计学意义(P=0.011)。结论:既往2次自然流产患者的胚胎质量下降;经系统、全面的自然流产原因筛查,并接受相应治疗后再行IVF-ET,自然流产次数≥3次的患者其受精率和优质胚胎率可有所提高。
[Abstract]:Objective: to investigate the relationship between the number of previous spontaneous abortion and the third day embryo quality. Methods: the data of patients treated with in vitro fertilization and embryo transfer (in vitro fertilization and embryo transfer,IVF-ET) for simple fallopian tube or pelvic adhesions were retrospectively analyzed, and the patients with known diseases affecting abortion and embryo development were excluded. The patients were divided into 4 groups according to the number of miscarriages. The patients were divided into 2 groups (n = 77) and 鈮，

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