济南地区孕中期妇女血清甲状腺激素参考值范围的建立及意义

发布时间：2018-09-01 11:20

【摘要】：目的建立济南地区正常孕中期妇女甲状腺激素参考值范围,并探讨其意义。方法采用美国雅培Abbott i2000化学发光仪测定济南地区545例单胎妊娠健康孕中期妇女、521例健康非妊娠妇女的甲状腺激素水平,采用双侧限值(P_(2.5)~P_(97.5))表示参考范围。结果孕中期妇女游离三碘甲状腺原氨酸(FT3)为3.52~5.56pmol/L,游离甲状腺素(FT4)为9.56~15.32 pmol/L,促甲状腺激素(TSH)为0.21~3.39μIU/m L;健康非妊娠妇女FT3为2.65~5.79 pmol/L,FT4为9.14~19.08 pmol/L,TSH为0.27~4.95μIU/m L;孕中期妇女FT3、FT4、TSH水平与健康非妊娠妇女相比,差异有统计学意义(P均0.05)。结论建立了济南地区孕中期妇女血清甲状腺激素参考范围,其中FT3为3.52~5.56 pmol/L、FT4为9.56~15.32 pmol/L、TSH为0.21~3.39μIU/m L,这有助于妊娠期甲状腺功能紊乱的临床诊疗。
[Abstract]:Objective to establish the reference range of thyroid hormone for normal women in the second trimester of pregnancy in Jinan and to explore its significance. Methods Abbott i2000 chemiluminescence instrument was used to measure the thyroid hormone levels in 545 healthy women with single pregnancy and 521 healthy non-pregnant women in Jinan area. The reference range was indicated by the bilateral limit (P2.5) and P97.5 (P _ (2. 5) P _ (97.5). Results the levels of free triiodothyronine (FT3) and free thyroxine (FT4) in women in second triiodothyronine (FT3) and free thyrotropin (FT4) in women with middle pregnancy were 3.52 卤5.56 pmol / L and 9.21 卤3.39 渭 IU/m / L, respectively. The FT3 of healthy non-pregnant women was 2.65 卤5.79 pmol/L,FT4 and 0.274.95 渭 IU/m / L, respectively, and the FT3,FT4,TSH level of women in second triiodothyronine (FT4) was 0.274.95 渭 IU/m / L compared with that in healthy non-pregnant women. The difference was statistically significant (P 0.05). Conclusion the reference range of serum thyroid hormone of women in the second trimester of pregnancy in Jinan area was established. The FT3 was 3.52 pmol/L,FT4 and 5.56 pmol/L,FT4 was 9.56 卤15.32 pmol/L,TSH and 0.21 渭 IU/m / L, which was helpful to the clinical diagnosis and treatment of thyroid dysfunction in pregnancy.
【作者单位】：武警山东总队医院;
【分类号】：R714.256

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