溴吡斯的明片联合甲磺酸多沙唑嗪片治疗老年女性宫颈癌术后尿潴留的临床研究

发布时间：2018-09-03 18:43

【摘要】：目的观察溴吡斯的明联合甲磺酸多沙唑嗪治疗老年女性宫颈癌术后尿潴留的临床疗效及安全性。方法将52例老年女性宫颈癌术后尿潴留患者随机分为对照组26例与试验组26例,2组患者均给予常规物理刺激。对照组给予甲磺酸多沙唑嗪片4 mg,每日1次,口服;试验组在对照组的基础上给予溴吡斯的明片60 mg,每日3次,口服。2组患者均用药7 d。治疗后,比较2组患者的临床疗效、尿动力学水平及药物不良反应发生情况。结果治疗后,试验组的总有效率为92.31%(24/26例),对照组为65.38%(17/26例),差异有统计学意义(P0.05)。治疗后,试验组残留尿量、膀胱最大容量、逼尿肌顺应性、最大尿流率、最大尿流率时逼尿肌压力分别为(40.14±5.57)mL,(300.19±31.89)mL,(32.00±4.18)cm H_2O,(10.02±1.43)mL·s~(-1),(25.71±3.14)cm H_2O;对照组分别为(69.88±8.37)mL,(5.02±0.53)mL,(56.39±6.19)mL·cm H_2O~(-1),(17.89±2.34)mL·s~(-1),(33.41±4.02)cm H_2O,差异均有统计学意义(P0.05)。试验组药物不良反应有恶心、呕吐、腹泻,药物不良反应发生率为15.38%(4/26例),对照组药物不良反应有恶心、呕吐、腹泻,药物不良反应发生率为11.54%(3/26例)。2组药物不良反应发生率比较,差异无统计学意义(P0.05)。结论溴吡斯的明联合甲磺酸多沙唑嗪治疗老年女性宫颈癌术后尿潴留的临床疗效显著,安全性较高。
[Abstract]:Objective to observe the clinical efficacy and safety of brompiridamine combined with doxazosin mesylate in the treatment of postoperative urinary retention in elderly women with cervical cancer. Methods 52 elderly women with postoperative urinary retention were randomly divided into control group (n = 26) and experimental group (n = 26). The control group was given doxazosin mesylate once a day for 4 mg, and the experimental group was given brompiridamine tablets 3 times a day for 60 mg, on the basis of the control group. After treatment, the clinical efficacy, urodynamic level and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rate was 92.31% (24 / 26 cases) in the experimental group and 65.38% (17 / 26 cases) in the control group. The difference was statistically significant (P0.05). 娌荤枟鍚，

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