HLA抗体的产生与孕妇妊娠次数关系的研究

发布时间：2018-09-03 19:23

【摘要】：目的研究HLA抗体的产生与孕妇妊娠次数的关系。方法选择2016年11月9日-2017年3月31日在邵逸夫医院下沙院区登记待产的24-28周856例孕妇为研究对象,收集其外周血血样,利用单克隆抗体固相血小板抗体实验检测孕妇血清中HLA抗体的表达情况。结果共检出HLA抗体阳性孕妇67例,抗体阳性率为7.8%。334例首次妊娠的孕妇中,有15例HLA阳性的,阳性率为4.5%;216例无流产史的两次或以上妊娠的孕妇中,有14例阳性,阳性率为6.5%;107例有一次流产史的孕妇中,有10例阳性,阳性率为9.3%;223例有两次及以上流产史的孕妇中,有28例阳性的,阳性率为12.6%。妊娠次数与HLA抗体发生率呈正相关。结论二次及以上妊娠的孕妇HLA抗体发生率高于首次妊娠的孕妇。
[Abstract]:Objective to study the relationship between the production of HLA antibody and the number of pregnancies in pregnant women. Methods from November 9, 2016 to March 31, 2017, 856 pregnant women of 24 to 28 weeks who were registered in Xiasha Hospital District of run Shaw Hospital were selected as study subjects, and their peripheral blood samples were collected. The expression of HLA antibody in maternal serum was detected by monoclonal antibody solid-phase platelet antibody test. Results A total of 67 pregnant women with positive HLA antibody were detected. The positive rate of HLA antibody was 7.8.334 pregnant women, 15 of them were HLA positive, and the positive rate was 4.55% of 216 pregnant women with no history of abortion, 14 of them were positive. Among 107 pregnant women with a history of abortion, 10 cases were positive, and the positive rate was 9.3223 cases with two or more miscarriages. 28 cases were positive and the positive rate was 12.6. The frequency of pregnancy was positively correlated with the incidence of HLA antibody. Conclusion the incidence of HLA antibody in pregnant women with second or above pregnancy is higher than that of pregnant women with first pregnancy.
【作者单位】：杭州市下沙医院;浙江大学医学院附属邵逸夫医院;
【分类号】：R714

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