唐氏综合征与先天性心脏病关系的回顾性研究
发布时间：2018-09-04 19:25
【摘要】：目的 探讨唐氏综合征（DS）与先天性心脏病（CHD）的关系。 方法 回顾性分析1997年1月至2013年3月重庆医科大学附属儿童医院收治的575例DS患者的临床资料，分析DS合并CHD的患病率、类型、染色体核型与CHD类型之间的关系、肺动脉压力及手术治疗情况。 结果 共收治575例DS患者，，合并CHD370例（64.35%），其中间隔类缺损322例（87.03%），包括ASD57例（15.41%），VSD36例（9.72%），AVSD12例（3.24%），复合间隔类缺损217例（58.65%）。非间隔缺损类先心（包括PDA、TOF、DORV、PA等）48例（12.97%）。DS不同核型与CHD类型无明显统计学差异。246例（66.49%）合并肺动脉压力升高。70例（18.92%）患者进行了介入或外科治疗，术后均有不同程度肺动脉压力下降。40例患者合并其他畸形，如胃肠道畸形、多指/趾、视力障碍等。 结论 DS与CHD发生密切相关。合并的CHD类型以间隔类缺损为主，ASD最为常见，其次为VSD。染色体核型与CHD类型无关。DS合并CHD容易早期出现肺动脉高压，应早期进行评估并制定综合治疗方案。
[Abstract]:Objective to investigate the relationship between Down's syndrome (DS) and congenital heart disease (CHD). Methods the clinical data of 575 DS patients admitted to the affiliated Children's Hospital of Chongqing Medical University from January 1997 to March 2013 were analyzed retrospectively. The prevalence, type, chromosome karyotype and CHD type of DS complicated with CHD were analyzed. Pulmonary artery pressure and surgical treatment. Results 575 cases (64.35%) of DS were treated, including 322 cases (87.03%) of septal defect, including 36 cases (9.72%) of ASD57 with VSD, and 217 cases (58.65%) of complex septal defect. 48 cases (12.97%) of non-septal defect (including PDA,TOF,DORV,PA et al). There was no significant difference between different karyotype of DS and CHD type. 246 cases (66.49%) were complicated with pulmonary artery pressure elevation. 70 cases (18.92%) were treated with interventional or surgical treatment. There were 40 patients with different degree of pulmonary artery pressure drop and other deformities, such as gastrointestinal malformation, multiple fingers / toes, visual impairment and so on. Conclusion DS is closely related to CHD. Septal defect was the most common type of CHD, followed by VSD.. Chromosome karyotype is not related to CHD type. DS combined with CHD is prone to early pulmonary hypertension.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.5
[Abstract]:Objective to investigate the relationship between Down's syndrome (DS) and congenital heart disease (CHD). Methods the clinical data of 575 DS patients admitted to the affiliated Children's Hospital of Chongqing Medical University from January 1997 to March 2013 were analyzed retrospectively. The prevalence, type, chromosome karyotype and CHD type of DS complicated with CHD were analyzed. Pulmonary artery pressure and surgical treatment. Results 575 cases (64.35%) of DS were treated, including 322 cases (87.03%) of septal defect, including 36 cases (9.72%) of ASD57 with VSD, and 217 cases (58.65%) of complex septal defect. 48 cases (12.97%) of non-septal defect (including PDA,TOF,DORV,PA et al). There was no significant difference between different karyotype of DS and CHD type. 246 cases (66.49%) were complicated with pulmonary artery pressure elevation. 70 cases (18.92%) were treated with interventional or surgical treatment. There were 40 patients with different degree of pulmonary artery pressure drop and other deformities, such as gastrointestinal malformation, multiple fingers / toes, visual impairment and so on. Conclusion DS is closely related to CHD. Septal defect was the most common type of CHD, followed by VSD.. Chromosome karyotype is not related to CHD type. DS combined with CHD is prone to early pulmonary hypertension.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.5
【参考文献】
相关期刊论文 前3条
1 张伟志;杨一峰;黄灿;赵天力;;Down综合征对先天性心脏病外科治疗的影响[J];中南大学学报(医学版);2012年07期
2 冯娟;王玉林;;儿童肺动脉高压遗传学及细胞分子学研究进展[J];实用儿科临床杂志;2006年22期
3 张t
本文编号：2223116
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2223116.html
最近更新
教材专著
