腹腔镜卵巢打孔术治疗多囊卵巢综合征的预测指标

发布时间：2018-09-07 12:08

【摘要】：腹腔镜卵巢打孔术目前已越来越多地应用于氯米芬抵抗的多囊卵巢综合征(PCOS)患者。腹腔镜卵巢打孔术可诱导单卵泡排卵,没有卵巢过度刺激综合征以及多胎妊娠的风险,获益时间可持续长达9年。但腹腔镜卵巢打孔术仅能使部分患者获益,对于一部分对腹腔镜卵巢打孔术不应答的女性,建立适当的术前预测指标能有效避免不必要的手术治疗。基于目前的证据,氯米芬抵抗的PCOS患者腹腔镜卵巢打孔术后不良生殖结局的可能预测指标包括:低基础LH水平、雄激素增多症的生物标志物(游离雄激素指数≥15,术前雄烯二酮水平4.1 mmol/L)、高基础抗苗勒管激素水平、不孕时长3.5年、年龄35岁,其中一些指标尚有争议,需进一步研究其与腹腔镜卵巢打孔术后生殖结局的关系。
[Abstract]:Laparoscopic ovarian perforation has been increasingly used in clomiphene resistant polycystic ovary syndrome (PCOS) patients. Laparoscopic ovarian drilling can induce single follicle ovulation without the risk of ovarian hyperstimulation syndrome and multiple pregnancy. However, laparoscopic ovarian perforation can only benefit some patients. For some women who do not respond to laparoscopic ovarian perforation, the establishment of appropriate preoperative predictors can effectively avoid unnecessary surgical treatment. Based on current evidence, potential predictors of poor reproductive outcomes after laparoscopic ovarian perforation in clomiphene resistant PCOS patients include low basic LH levels. The biomarker of androgen hypertrophy (free androgen index 鈮，

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