E-钙黏素在复发性流产孕妇妊娠早期滋养层细胞中的表达与HPV感染的相关性分析
发布时间：2018-09-09 15:37
【摘要】：目的探讨复发性流产孕妇妊娠早期滋养层细胞中E-钙黏素表达状况,并分析E-钙黏素与人乳头状瘤病毒(HPV)感染间的相关性。方法选取医院2016年1月-12月120例妊娠早期复发性流产孕妇临床诊治资料,设为观察组,另选取120例同期于医院行人工流产的正常早期妊娠孕妇作为对照组,采集两组绒毛标本,检测两组绒毛滋养细胞中E-钙黏素表达状况,同时统计两组HPV-DNA感染情况。结果两组切片中均可见E-钙黏素阳性表达,其中观察组E-钙黏素阳性者69例,阳性率为57.50%显著低于对照组E-钙黏素阳性者111例,阳性率92.50%(P0.05)。观察组HPV感染者42例,感染率35.00%,显著高于对照组HPV感染者15例,感染率12.50%(P0.05);观察组HPV感染中HPV16感染占85.71%,显著高于对照组40.00%(P0.05)。HPV感染孕妇中E-钙黏素阳性者为15例,E-钙黏素阳性率35.71%显著低于对照组E-钙黏素阳性者为15例,E-钙黏素阳性率100.00%(P0.05)。E-钙黏素表达与HPV感染进行相关性分析,两者呈负相关性(P0.05)。结论 E-钙黏素在妊娠早期孕妇滋养层细胞中存在阳性表达,而E-钙黏素阳性表达下降可能参与到复发流产过程中;孕妇感染HPV尤其是HPV16感染则可能会致E-钙黏素异常表达。
[Abstract]:Objective to investigate the expression of E-cadherin in trophoblastic cells of pregnant women with recurrent abortion and to analyze the correlation between E-cadherin and human papillomavirus (HPV) infection. Methods 120 pregnant women with early recurrent abortion in hospital from January to December 2016 were selected as observation group and 120 normal early pregnant women who underwent artificial abortion in hospital as control group, and two groups of villi were collected. The expression of E-cadherin in chorionic trophoblast and HPV-DNA infection in two groups were measured. Results the positive expression of E-cadherin was found in both groups. The positive rate of E-cadherin in observation group was 57.50%, which was significantly lower than that in control group (111 cases), the positive rate was 92.50% (P0.05). There were 42 cases of HPV infection in the observation group, and the infection rate was 35.00%, which was significantly higher than that in the control group (15 cases of HPV infection). The infection rate of Ecadherin was 12.50% (P0.05) in the observation group and 85.71% in the HPV infection group, which was significantly higher than that in the control group (40.00%). The positive rate of Ecadherin in 15 pregnant women with HPV infection was 35.71% lower than that in the control group (35.71%). The correlation between the expression of E-cadherin and HPV infection was analyzed in 100.00% (P0.05). There was a negative correlation between them (P0.05). Conclusion there is a positive expression of E-cadherin in trophoblastic cells of pregnant women in early pregnancy, and the decrease of positive expression of E-cadherin may be involved in the process of recurrent abortion, and the abnormal expression of E-cadherin in pregnant women may be caused by HPV infection, especially HPV16 infection.
【作者单位】： 浙江省台州医院妇产科;
【基金】：浙江省自然科学基金-青年基金资助项目(Q13H160045)
【分类号】：R714.21
本文编号：2232799
[Abstract]:Objective to investigate the expression of E-cadherin in trophoblastic cells of pregnant women with recurrent abortion and to analyze the correlation between E-cadherin and human papillomavirus (HPV) infection. Methods 120 pregnant women with early recurrent abortion in hospital from January to December 2016 were selected as observation group and 120 normal early pregnant women who underwent artificial abortion in hospital as control group, and two groups of villi were collected. The expression of E-cadherin in chorionic trophoblast and HPV-DNA infection in two groups were measured. Results the positive expression of E-cadherin was found in both groups. The positive rate of E-cadherin in observation group was 57.50%, which was significantly lower than that in control group (111 cases), the positive rate was 92.50% (P0.05). There were 42 cases of HPV infection in the observation group, and the infection rate was 35.00%, which was significantly higher than that in the control group (15 cases of HPV infection). The infection rate of Ecadherin was 12.50% (P0.05) in the observation group and 85.71% in the HPV infection group, which was significantly higher than that in the control group (40.00%). The positive rate of Ecadherin in 15 pregnant women with HPV infection was 35.71% lower than that in the control group (35.71%). The correlation between the expression of E-cadherin and HPV infection was analyzed in 100.00% (P0.05). There was a negative correlation between them (P0.05). Conclusion there is a positive expression of E-cadherin in trophoblastic cells of pregnant women in early pregnancy, and the decrease of positive expression of E-cadherin may be involved in the process of recurrent abortion, and the abnormal expression of E-cadherin in pregnant women may be caused by HPV infection, especially HPV16 infection.
【作者单位】： 浙江省台州医院妇产科;
【基金】：浙江省自然科学基金-青年基金资助项目(Q13H160045)
【分类号】：R714.21
【相似文献】
相关期刊论文 前6条
1 李红英,刘少扬,江大琼;E-钙黏素和α、β-连接素在子宫颈癌组织中的表达[J];中华妇产科杂志;2004年12期
2 王立宏,李亚里,刘爱军;E-钙黏素及β-连环素在子宫内膜异位症中的表达[J];解放军医学杂志;2004年07期
3 高媛;曲們們;;妇科肿瘤与E钙黏素启动子甲基化研究进展[J];国外医学.妇产科学分册;2006年02期
4 姚守珍;刘玲;王璐璐;;复发性流产孕妇早期妊娠滋养细胞中E-钙黏素的表达与HPV感染的相关性[J];中华医院感染学杂志;2014年12期
5 史惠蓉;任芳;乔玉环;;卵巢上皮性肿瘤组织中EphA2和E-钙黏素测定[J];郑州大学学报(医学版);2007年01期
6 周行;奉泽锦;韩亮;韩志蓉;张文先;;E-钙黏素和骨桥蛋白在子宫颈癌患者中的表达及意义[J];中国妇产科临床杂志;2013年04期
相关硕士学位论文 前1条
1 张勤建;E-钙黏素和胎盘病态附着发病关系的研究[D];福建医科大学;2015年
，本文编号：2232799
本文链接：https://www.wllwen.com/yixuelunwen/fuchankeerkelunwen/2232799.html
最近更新
教材专著
