血清PTX3与子痫前期及肾功能损害的相关性研究

发布时间：2018-09-11 13:41

【摘要】：【目的】探讨血清PTX3与子痫前期的关系，以及与子痫前期患者并发肾功能损害的相关性。【方法】选取苏州大学附属第一医院2013年9月至2014年2月于产科病房住院孕产妇75例，包括轻度子痫前期组（MPE组）25例，，重度子痫前期组（SPE组）25例，同期健康的孕妇25例作为对照组，采用酶联免疫吸附法测定各组实验对象血清五聚素3的浓度，同时进行超敏C反应蛋白（hsCRP）、平均动脉压、24小时尿蛋白定量、中性粒细胞比率、尿酸、肌酐、尿素氮等各临床指标检测。【结果】（1）对照组、MPE组、SPE组三组血清PTX3值的水平分别为：（4.51±1.45）ng/ml、（7.75±1.41）ng/ml、（9.81±2.47）ng/ml，MPE组、SPE组孕妇血清中PTX3水平均高于对照组（P＜0.05），其中SPE组高于正常对照组（P＜0.01），SPE组高于MPE组（P＜0.05），且差异均具有统计学意义（P＜0.05）。（2）三组孕妇血清中PTX3水平与平均动脉压、中性粒细胞比率，24小时尿蛋白、及肾功能指标尿酸、肌酐、尿素氮水平呈正相关关系（0＜r＜1，P＜0.05）；三组孕妇血清中hsCRP的表达水平与平均动脉压、中性粒细胞比率呈正相关关系（0＜r＜1，P＜0.05），而与24小时尿蛋白，及肾功能指标尿酸、肌酐、尿素氮无直线相关关系（P＞0.05），两者均与BMI、孕周无直线相关关系（P＞0.05）。（3）将试验所得血清PTX3、hsCRP浓度进行ROC曲线分析，可见PTX3曲线下面积达0.905，hsCRP曲线下面积达0.821，提示PTX3对子痫前期疾病的诊断具有一定的准确性，且价值较hsCRP高。【结论】PTX3不仅与子痫前期的发生有关，且其表达水平与疾病的严重程度相关，亦可作为子痫前期肾功能损害的监测指标，且对子痫前期诊断的价值较hsCRP高。
[Abstract]:[objective] to investigate the relationship between serum PTX3 and preeclampsia, and the correlation between serum PTX3 and preeclampsia complicated with renal function damage. [methods] 75 pregnant women in obstetrical wards from September 2013 to February 2014 were selected from the first affiliated Hospital of Suzhou University. There were 25 cases of mild preeclampsia group (MPE group), 25 cases of severe preeclampsia group (SPE group) and 25 cases of healthy pregnant women as control group. At the same time, 24 hours urinary protein quantification, neutrophil ratio, uric acid, creatinine were measured by (hsCRP), mean arterial pressure. [results] (1) the serum PTX3 levels in the control group were (4.51 卤1.45) ng/ml, (7.75 卤1.41) ng/ml, (9.81 卤2.47) ng/ml,MPE were higher than those in the control group (P < 0. 05), and the serum PTX3 level in the SPE group was higher than that in the normal control group (P < 0. 05). The serum PTX3 level and mean arterial pressure in the three groups were significantly higher than those in the MPE group (P < 0. 01), and the difference was statistically significant (P < 0. 05). There was a positive correlation between urinary protein in 24 hours of neutrophil ratio, uric acid, creatinine and urea nitrogen levels (0 < r < 1, P < 0. 05), and the expression of hsCRP in serum of the three groups was correlated with the mean arterial pressure. There was a positive correlation between neutrophil ratio (0 < r < 1g P < 0.05) and 24 hours urine protein, uric acid, creatinine, renal function index. There was no linear correlation between urea nitrogen and BMI, (P > 0. 05). There was no linear correlation between urea nitrogen and BMI, during gestational age (P > 0. 05). (3). The serum PTX3,hsCRP concentration was analyzed by ROC curve. It can be seen that the area under the PTX3 curve is 0.821, suggesting that PTX3 has a certain accuracy in the diagnosis of pre-eclampsia disease and its value is higher than that of hsCRP. [conclusion] PTX3 is not only related to the occurrence of pre-eclampsia, but also to the diagnosis of pre-eclampsia. The expression level was correlated with the severity of the disease and could also be used as a monitoring index for renal damage in preeclampsia. The diagnostic value of preeclampsia was higher than that of hsCRP.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.244;R714.258

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